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The LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies against Alzheimer's disease. This is stated in the recent studies by the Research Group on Medicinal Chemistry and Pharmacology of Neurodegenerative Diseases of the University of Barcelona, published […]

After receiving a COVID-19 vaccine, many experience mild yet common symptoms, such as headache, fatigue and muscle pain – side effects reported by more than 100,000 Australians to date in a national survey. These vaccine side effects have led to hesitancy in some younger people, who may have more symptoms following a […]

Adults with ADHD are at higher risk of a wide range of physical conditions, including nervous system, respiratory, musculoskeletal, and metabolic diseases, according to a large register-based study from Karolinska Institutet published in The Lancet Psychiatry. “Identifying co-occurring physical diseases may have important implications for treating adults with ADHD and […]

Research ID's immune cells that sculpt inhibitory neurons, regulate brain wiring. From the bark of a puppy to the patter of rain against the window, our brains receive countless signals every second. Most of the time, we tune out inconsequential cues—the buzz of a fly, the soft rustle of leaves […]

A transplant of healthy gut microbes followed by fibre supplements benefits patients with severe obesity and metabolic syndrome, according to University of Alberta clinical trial findings published in Nature Medicine. Patients who were given a single-dose oral faecal microbial transplant followed by a daily fibre supplement were found to have better […]

The COVID vaccines currently being deployed were developed with unprecedented speed, but the mRNA technology at work in some of them is an equally impressive success story. Because any desired mRNA sequence can be synthesized in massive quantities, one of the biggest hurdles in a variety of mRNA therapies is […]

Patients who had their wisdom teeth extracted had improved tasting abilities decades after having the surgery, a new Penn Medicine study published in the journal Chemical Senses found. The findings challenge the notion that removal of wisdom teeth, known as third molars, only has the potential for negative effects on taste, and represent one of […]

Our cells have abilities that go far beyond the fastest, smartest computer. They generate mechanical forces to propel themselves around the body and sense their local surroundings through a myriad of channels, constantly recalibrating their actions. The idea of using cells as medicine emerged with bone marrow transplants, and then […]

Researchers studying COVID-19 patients have found a metabolic pathway that is highly correlated with immune responses only in male patients, a group known to be more likely to suffer severe cases and die of the disease, representing a potential target for therapeutic intervention. In a study published in the journal […]

In the future, it could be possible to stimulate the immune system with extremely high efficacy via the skin. Cutanos GmbH, a spin-off from the Max Planck Institute of Colloids and Interfaces, has developed a corresponding method for modulating immune cells in the skin. The LC-TDS technology makes it possible […]

University of California San Diego School of Medicine researchers have identified a possible link between inadequate exposure to ultraviolet-B (UVB) light from the sun and an increased risk of colorectal cancer, especially as people age. Reporting in the journal BMC Public Health, researchers investigated global associations between levels of UVB light […]

Researchers from Ernst Federal Science Center for Animal Husbandry, Skoltech, Moscow State University and their colleagues have produced the first viable cloned calf in Russia – and she recently turned one. In a related experiment, the team was able to knock out the genes responsible for beta-lactoglobulin, a protein causing […]

Researchers from Skoltech and the Mental Health Research Center have found 22 lipids in the blood plasma of people with schizophrenia that were associated with lower symptom improvement over time during treatment. These can help track resistance to medication that affects over a third of patients. The paper was published in the journal Biomolecules. […]

Mayo Clinic researchers are taking a close look at rare cases of inflammation of the heart muscle, or myocarditis, in young men who developed symptoms shortly after receiving the second dose of the Moderna or Pfizer messenger RNA (mRNA) COVID-19 vaccines. Several recent studies suggest that health care professionals should watch for hypersensitivity […]

Researchers at Karolinska Institutet publish new findings in the journal Cancer Discovery showing how pharmacological activation of the protein p53 boosts the immune response against tumours. The results can be of significance to the development of new combination therapies that will give more cancer patients access to immunotherapy. Given its […]

In 2017, Green Bay Packers quarterback Aaron Rodgers broke his right collarbone in a game against the Minnesota Vikings. Typically, it takes about 12 weeks for a collarbone to fully heal, but by mid-December fans and commentators were hoping the three-time MVP might recover early and save a losing season. […]

Studies reveal unprecedented mechanism behind loss of antibody neutralization against this pandemic coronavirus variant of concern. Three mutations in the Epsilon coronavirus Spike protein dampen the neutralizing potency of antibodies induced by current vaccines or past COVID infections. The mutations give this coronavirus variant of concern a means to totally […]

Flies have discriminating taste. Like a gourmet perusing a menu, they spend much of their time seeking sweet nutritious calories and avoiding bitter, potentially toxic food. But what happens in their brains when they make these food choices? Yale researchers discovered an interesting way to find out. They tricked them. […]

Using Argonne National Laboratory’s Advanced Photon Source, researchers have determined the structure of an enzyme that plays a key role in the spread of cancer cells. Chances are, every one of us has been affected by cancer in one way or another. Unlike some other deadly diseases, cancer can take […]

The psychedelic drug psilocybin, a naturally occurring compound found in some mushrooms, has been studied as a potential treatment for depression for years. But exactly how it works in the brain and how long beneficial results might last is still unclear. In a new study, Yale researchers show that a […]

Academics at Cardiff University carried out a systematic review of 118 published observational studies in patients with 18 different cancers. They pooled the results and found that in a total of about 250,000 patients with cancer who reported taking aspirin, this was associated with a reduction of about 20% in […]

A new study involving Liverpool researchers has shown that many of the symptoms in fibromyalgia syndrome (FMS) are caused by antibodies that increase the activity of pain-sensing nerves throughout the body. The results show that fibromyalgia is a disease of the immune system, rather than the currently held view that […]

A year after University at Buffalo scientists demonstrated that it was possible to produce millions of mature human cells in a mouse embryo, they have published a detailed description of the method so that other laboratories can do it, too. The ability to produce millions of mature human cells in […]

In addition to sickening and taking the lives of millions across the globe, COVID-19 complicated patient care in a range of less direct ways, from increased incidence of heart attacks to decreased cancer screenings.  The virus also increased the risk of complications and death among trauma patients with injuries from car crashes, falls […]

It is not shocking to anyone that fat molecules are tied to heart conditions. Lipids, a term for fatty acids and their derivatives, are the subject of countless papers when it comes to cardiovascular disease. A keyword search for “lipid” on the Journal of the American Heart Association’s website alone returns more than 2,600 results. So, if […]

The question of how reproductive cells like sperm and eggs maintain their DNA integrity during development is at the heart of a new study by student researchers in the lab of molecular biologist Diana Libuda. DNA damage occurs dozens or even hundreds of times within each individual developing sperm or […]

A sizable enough fraction of T cells of the adaptive immune system become senescent in old age to cause major issues. Senescent cells cease replication and secrete a mix of signals that cause harm in numerous different ways: rousing chronic inflammation; disrupting tissue maintenance and structure; encouraging other cells to […]

Microglia are innate immune cells of the central nervous system, responsible for clearing harmful molecular waste, tracking down pathogens, and a range of other supporting roles in the function and tissue maintenance of the brain. Unfortunately microglia are known to become dysfunctional with age: notable more inflammatory, and less capable […]

In cancer research, it’s a common goal to find something about cancer cells — some sort of molecule — that drives their ability to survive, and determine if that molecule could be inhibited with a drug, halting tumor growth. Even better: The molecule isn’t present in healthy cells, so they […]

Researchers have discovered a specific brain region underlying ‘goal-directed behaviour’ – that is, when we consciously do something with a particular goal in mind, for example going to the shops to buy food. The study, published in the journal Neuron, found that marmoset monkeys could no longer make an association between […]