General

A new study published in Science, has revealed how the master switch for hunger in the brain, the melanocortin receptor 4 (MC4), works. The research team, including scientists from the Weizmann Institute of Science, Queen Mary University of London and the Hebrew University of Jerusalem, also clarified how this switch is […]

A national, University at Buffalo-led study on genes in pediatric cardiomyopathy demonstrates strong evidence for routine genetic screening in children with the disease. The study, published in the Journal of the American Heart Association, revealed wide variation in screening, with some centres conducting routine genetic testing and others conducting none. […]

The immune response to tuberculosis (TB) differs in adults and newborn babies due to the way immune cells use energy to kick into gear in a bid to kill the bacteria. This fresh discovery – just published in leading journal, Frontiers in Immunology – offers hope for improving treatments for what remains […]

Drugs and vaccines circulate through our vascular system reacting according to their chemical and structural nature. In some cases, their destination is diffuse. In other cases, like cancer treatments, the intended target is highly localized. The effectiveness of a medicine —and how much is needed and the amount of side-effects […]

A University of Alberta researcher is using nanotechnology to improve the effectiveness of chemotherapy treatments for cancer patients and reduce their side effects. Afsaneh Lavasanifar is a professor in the University of Alberta’s Faculty of Pharmacy & Pharmaceutical Sciences and an adjunct professor in the Department of Chemical and Medical Engineering. Her lab develops […]

Experimental Alzheimer’s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer’s therapies are more effective when paired with a treatment geared toward improving drainage of fluid — and debris — from […]

Innovative multidisciplinary research at Washington University led to development of 'breakthrough' device. A first-of-its-kind device that helps people disabled by stroke regain significant control over their arm and hand function by using their minds has received market authorization from the Food and Drug Administration (FDA). The IpsiHand Upper Extremity Rehabilitation […]

Brain changes in people with Alzheimer’s disease and in those with mild traumatic brain injuries have significant similarities, a new USC study shows, suggesting new ways to identify patients at high risk for Alzheimer’s. The findings appeared in GeroScience. Traumatic brain injuries, or TBIs, affect over 1.7 million Americans every […]

Enhancing the brain’s lymphatic system when administering immunotherapies may lead to better clinical outcomes for Alzheimer’s disease patients, according to a new study in mice. Results published in Nature suggest that treatments such as the immunotherapies BAN2401 or aducanumab might be more effective when the brain’s lymphatic system can better drain […]

Scientists have made a pivotal breakthrough in understanding the way in which cells communicate with each other. A team of international researchers, including experts from the University of Exeter’s Living Systems Institute, has identified how signalling pathways of Wnt proteins – which orchestrate and control many cell developmental processes – […]

Pioneering research led by experts from the University of Exeter’s Living Systems Institute has provided new insight into formation of the human embryo. The team of researchers discovered an unique regenerative property of cells in the early human embryo. The first tissue to form in the embryo of mammals is […]

Researchers have discovered an explanation for why cerebral cavernous malformations (CCMs)—clusters of dilated blood vessels in the brain—can suddenly grow to cause seizures or stroke. Specifically, they found that a specific, acquired mutation in a cancer-causing gene (PIK3CA) could exacerbate existing CCMs in the brain. Furthermore, repurposing an already existing […]

Scientists have made a promising step towards developing a new drug for treating acute myeloid leukaemia, a rare blood disorder. In a study published today in Nature, Cambridge researchers report a new approach to cancer treatment that targets enzymes which play a key role in translating DNA into proteins and which […]

A new way to identify tumours that could be sensitive to particular immunotherapies has been developed using data from thousands of NHS cancer patient samples sequenced through the 100,000 Genomes Project. The MMRDetect clinical algorithm makes it possible to identify tumours that have ‘mismatch repair deficiencies’ and then improve the personalisation of cancer therapies to exploit […]

Professor Naoto Hirano of the Temerty Faculty of Medicine and collaborators have developed a new technology that rigorously and robustly identifies the immune cells that are capable of recognizing and eliminating cancer cells. The findings, published in Nature Biotechnology, pave the way for novel immunotherapies to help more patients, regardless of their genetic ancestry, […]

New research from the University of Virginia School of Medicine has shed light on the No. 1 cause of epilepsy deaths, suggesting a long-sought answer for why some patients die unexpectedly following an epileptic seizure. The researchers found that a certain type of seizure is associated with sudden death in a […]

Cryopreservation, or the long-term storage of biomaterials at ultralow temperatures, has been used across cell types and species. However, until now, the practical cryopreservation of the fruit fly (Drosophila melanogaster) — which is crucial to genetics research and critical to scientific breakthroughs benefiting human health — has not been available. […]

Stretching out the DNA in all 46 chromosomes packed into one human cell would make a string of DNA two meters long. Accurately replicating all that DNA is vital to survival; cells must control this process with tremendous precision in time and space. Origin recognition complexes (ORCs) initiate the task […]

From cancer treatment to sunlight, radiation and toxins can severely damage DNA in both harmful and healthy cells. While the body has evolved to efficiently treat and restore damaged cells, the mechanisms that allow this natural repair remain misunderstood. In a new study, Northwestern University researchers have used cryogenic electron […]

A multi-institutional team of researchers has identified both the genetic abnormalities that drive pre-cancer cells into becoming an invasive type of head and neck cancer and patients who are least likely to respond to immunotherapy. “Through a series of surprises, we followed clues that focused more and more tightly on […]

How do different parts of the brain communicate with each other during learning and memory formation? A new study by researchers at the University of California San Diego takes a first step at answering this fundamental neuroscience question. The study was made possible by developing a neural implant that monitors […]

In almost ten per cent of myocardial infarctions, no obvious cause in the coronary artery can be found. Some of the patients are diagnosed with the broken-heart syndrome, while others are left without a diagnosis. A new study from Karolinska Institutet in Sweden suggests that early magnetic resonance (MR) imaging […]

COVID-19 patients who are overweight or obese have more severe symptoms and are highly likely to require invasive respiratory support, according to a new international study. The research, led by The University of Queensland and the Murdoch Children’s Research Institute (MCRI), found obese patients had a 73 per cent greater chance of […]

The COVID-19 vaccine isn’t having any trouble attracting suitors. But there’s another, an older model that’s been mostly ignored by the young men of America: the HPV vaccine. Using data from the 2010-2018 National Health Interview Surveys, Michigan Medicine researchers found that just 16% of men who were 18 to […]

When a person views a familiar image, even having seen it just once before for a few seconds, something unique happens in the human brain. Until recently, neuroscientists believed that vigorous activity in a visual part of the brain called the inferotemporal (IT) cortex meant the person was looking at […]

Traits that allow cancer cells to escape the body’s natural defence system and develop into tumours are actually a good indicator to a patient’s survival prognosis, according to University of Queensland researchers. UQ Diamantina Institute researcher Dr Janin Chandra described the discovery as a “catch-22 situation” and good news for patients with either […]

The heart damage seen in many severely ill COVID-19 patients results in part from infection-activated immune cells called macrophages, which infiltrate the heart and secrete cell-damaging chemicals, according to a study co-led by researchers at Weill Cornell Medicine, NewYork-Presbyterian, Icahn School of Medicine at Mt. Sinai and Columbia University Irving […]

Researchers at Karolinska Institutet have found links between certain blood groups and a total of 49 diseases, including a new finding that having blood group B seems to be a protective factor against kidney stones. The study, which includes data on more than five million people and over 1,000 diseases, […]

Millions of people face the loss of their eyesight from degenerative eye diseases. The genetic disorder retinitis pigmentosa alone affects 1 in 4,000 people worldwide. Today, there is technology available to offer partial eyesight to people with that syndrome. Argus II, the world's first retinal prosthesis, reproduces some functions of […]

Obesity is associated with an increased risk for a broad spectrum of tumors, including colon cancer. And once cancer develops, statistics show that overweight or obese individuals are at higher risk of cancer recurrence and have a decreased chance of survival. The underlying mechanisms for this are unclear. One of […]