General

Excess sugar in the blood, the central feature of diabetes, can react with immune proteins to cause myriad changes in the immune system, including inflammatory changes that promote atherosclerosis, according to a new study from scientists at Weill Cornell Medicine and University of Massachusetts Medical School. The study, published in […]

Radiation therapy appears to increase the expression of genes with mutations that induce an immune response to malignant cells, according to preclinical research by Weill Cornell Medicine and NewYork-Presbyterian investigators. The findings suggest that radiation treatment directed to tumors in mice may help to improve a form of immunotherapy that […]

Next time you reward a child with a treat, consider offering fruit, nuts or a cereal bar instead of ice cream or candy, a Cornell economist suggests. Research by an international team including Michèle Belot, professor in the Department of Economics, found that children valued a sweet food more after receiving […]

Supplementation of cocoa powder in the diet of high-fat-fed mice with liver disease markedly reduced the severity of their condition, according to a new study by Penn State researchers, who suggest the results have implications for people. Cocoa powder, a popular food ingredient most commonly used in the production of […]

In the journal “Nature Communications”, scientists of the German Center for Neurodegenerative Diseases (DZNE) report new findings on the mechanisms of “Niemann-Pick type C disease” (NPC). This rare brain disorder mainly manifests in childhood and includes severe neurological and psychiatric symptoms. Researchers led by Dr. Sabina Tahirovic have now found […]

More than 20 years after the launch of a landmark clinical trial, follow-up examinations and analyses found that not all patients with elevated eye pressure need pressure-lowering treatment to prevent vision loss from glaucoma. When the study was launched, it was universally accepted that all patients with elevated eye pressure […]

A new study investigates a genetic culprit behind abdominal aortic aneurysm, a serious condition that puts people at risk of their aorta rupturing – a potentially deadly event. Finding a viable genetic target for AAA could change the game, says senior author Katherine Gallagher, M.D., a vascular surgeon and an associate professor of […]

More than half of cervical cancer cases in the United States occur in women who have not had timely Pap smears and/or HPV tests — screenings that allow for detection of precancerous or cancerous cells on the cervix. Encouraging low-income women, in particular, to participate in such screenings likely would […]

A new study from Cold Spring Harbor Laboratory (CSHL) Research Investigator Katharina Schmack and Adjunct Professor Adam Kepecs uncovered how hallucinations are produced in human and mouse brains. Their new mouse model for hallucination-like behaviours should help uncover mechanisms and treatments for schizophrenia. Schmack was working as a psychiatrist at the Charité–Universitätsmedizin Berlin […]

For a while now, heart disease researchers have known that a protein called GRK5 – expressed throughout the body, though most notably in the lungs, heart, and placenta – normally dwells in the outer membrane of heart cells and, upon exposure to stress, moves into the cell nucleus, switching on […]

The results of this epidemiological study suggest that suffering from untreated sleep apnea can raise the risk of later dementia and mild cognitive impairment by 20-30%. How the repeated hypoxia in the brain produced by sleep apnea results in a raised risk of dementia isn't understood in detail, but it […]

Researchers at the University of Alberta are looking for ways to prevent or slow cachexia, a muscle-wasting syndrome thought to cause up to a third of the 80,000 deaths related to cancer every year in Canada. By understanding the role of activin A, a growth factor that contributes to muscle […]

Scientists have figured out how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into what’s known as the epigenome – proteins and small molecules that latch onto DNA and control when and where genes are switched on or off. In a paper published in the […]

Research from the University of Wisconsin–Madison finds that a new therapeutic approach for heart failure could help restore cardiac function by regenerating heart muscle. In a study recently published in the journal Circulation, the UW team describes its success in improving, in a mouse model, the function of heart muscle by […]

At its most basic level, it takes pictures. For UW–Madison biochemistry professor Elizabeth Wright, that’s the scaled-down explanation of cryogenic electron microscopy or cryo-EM. But it’s so much more than that. Through rapid freezing, controlled beams, and advanced lenses, this game-changing research tool reveals the intricate architecture of cells, viruses, and […]

Researchers at the DZNE (Germany), at Massachusetts General Hospital (USA) and at the genomic medicine company Sangamo Therapeutics, Inc. tested a novel gene regulation approach to treat brain diseases such as Alzheimer's in laboratory studies. It leverages zinc finger proteins, which specifically bind to the DNA that codes for the […]

McMaster University researchers have discovered a new treatment that could bring relief to millions of people worldwide living with peanut allergy. The current understanding is that in certain individuals, the immune system mistakenly identifies a specific food protein as harmful and triggers the production of an antibody called Immunoglobulin E […]

Despite surgery and subsequent treatment with chemotherapy and radiation, the majority of patients experience recurrence of malignant brain tumours. Researchers at Linköping University, Sweden, and the Medical University of Graz, Austria, have shown in cells in culture that an ion pump can deliver drugs more accurately, which gives less severe […]

A global study led by Hamilton scientists has found a link between eating processed meat and a higher risk of cardiovascular disease. The same study did not find the same link with unprocessed red meat or poultry. The information comes from the diets and health outcomes of 134,297 people from […]

Potentially game-changing research led by McMaster University scientists may finally bring relief to millions of people worldwide living with Crohn’s disease. Investigator Brian Coombes said his team identified a strain of adherent-invasive E-coli (AIEC) that is strongly implicated in the condition and is often found in the intestines of people […]

New research from the Florida State University College of Medicine has found that the personality trait neuroticism is consistently associated with a higher risk of developing the brain disorder Parkinson’s disease. The research by Professor of Geriatrics Antonio Terracciano and team, published in Movement Disorders, found that adults in the study […]

The causes of the serious muscle disease ALS still remain unknown. Now, researchers at Karolinska Institutet and KTH Royal Institute of Technology, among others, have examined a type of cell in the brain blood vessels that could explain the unpredictable disease origins and dynamics. The results indicate a hitherto unknown […]

Humans evolved in an environment of physical exertion, and our biochemistry requires physical exertion in order to trigger mechanisms of cell maintenance and metabolic regulation. Populations that exercise vigorously into late old age, such as the Tsimane in Bolivia, exhibit very much lower levels of cardiovascular disease. Further, living a […]

Imagine a drug that could temporarily reenergize plasticity in the brain to treat autism or schizophrenia, or even help an adult’s ageing brain pick up a new language or learn to play a musical instrument. Such are the potential, down-the-road medical implications of a discovery made by a postdoctoral researcher […]

Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania. Changing the microenvironment from so-called T cell […]

A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer’s disease patients. If perfected in humans, the technique could be used as an alternative approach to immunotherapy and used to treat other diseases caused by similar […]

Groundbreaking research from Tel Aviv University may lead to a significant breakthrough in the battle against deadly brain cancer. TAU researchers have identified a failure in the brain’s immune system that leads to the amplification of cell division and the spread of glioblastoma cancer cells. The failure results partially from the secretion […]

High expression levels of the gene TRIM63 can serve as an accurate and sensitive biomarker of a subtype of kidney cancer known as microphthalmia-associated transcription factor family aberration-associated renal cell carcinomas — or MiTF renal cell carcinoma. That’s according to a new, multi-institution study led by researchers at the University of Michigan Center for Translational […]

Alcohol-related liver disease is on the rise in the United States. Most strikingly, this epidemic is disproportionally affecting young, otherwise healthy, people, leading to rapid increases in alcohol-related liver disease deaths. “Changes in mortality rates for the alcohol-related liver disease vary significantly from state to state, so we think socioeconomic […]

Non-alcoholic fatty liver disease, NAFLD, is associated with several health risks. According to a new registry study led by researchers at Karolinska Institutet in Sweden, NAFLD is linked to a 17-fold increased risk of liver cancer. The findings, published in Hepatology, underscore the need for improved follow-up of NAFLD patients […]