General

Professor Martijn Nawijn, an immunologist at the University of Groningen in the Netherlands, tells Horizon Magazine about his quest to map every cell in a healthy human lung.  He says this work should help to understand more about the causes of lung disease – which is comparatively understudied – and should lead to new therapies in the next 15 to […]

Scientists reveal that high blood pressure increases lung damage risk in patients with cancer who receive bleomycin chemotherapy. Bleomycin is a drug used to treat certain cancers, such as Hodgkin lymphoma and germ cell tumors. But, bleomycin chemotherapy can cause near-fatal lung damage, a condition called bleomycin-induced lung injury. Now, […]

An international team of scientists has sequenced the genome of a capuchin monkey for the first time, uncovering new genetic clues about the evolution of their long lifespan and large brains. Published in PNAS, the work was led by the University of Calgary in Canada and involved researchers at the University […]

Statistical modeling developed by Oregon State University researchers has confirmed that changes to melanoma patients’ gut microbiome led them to respond to a type of treatment capable of providing long-term benefit. Findings were published in Science. The modeling technique invented by Andrey Morgun of the OSU College of Pharmacy and Natalia […]

A study led by researchers at the University of Minnesota Medical School found a way to detect the presence of ovarian cancer in patients using Pap test samples, normally used to detect cervical cancer. Currently, no early warning system exists for ovarian cancer, which in 2021, is estimated to kill […]

Bilingual people can effortlessly switch between languages during everyday interactions. But beyond its usefulness in communication, being bilingual could affect how the brain works and enhance certain abilities. Studies into this could inform techniques for learning languages and other skills. More than half of people in Europe speak more than […]

Astrocytes — star-shaped cells in the brain that are actively involved in brain function — may play an important role in stuttering, a study led by a University of California, Riverside, an expert on stuttering has found. “Our study suggests that treatment with the medication risperidone leads to increased activity […]

Advances in diagnosis and care have yielded significant improvements in childhood cancer survival rates in Europe, but the long-term side-effect burden in young people — driven by the unlicensed use of adult cancer medicines — often means the price of survival is high, scientists say. Prescribing unlicensed drugs or the ‘off-label’ use […]

Many cancer patients might respond better to treatments with the help of a new prognostic indicator based on a distinctive pattern of gene activity within tumor cells, according to a new study of human cancer data and experiments on human cancer cell lines grown in the lab. The new research, […]

Anti-retroviral drugs are a vital tool in the prevention and treatment of HIV. A new study of pregnant women in Tanzania shows that life-long antiviral treatment also seems to prevent viral transmission from mother to baby. The results of the study, which was conducted in part by researchers at Karolinska […]

AI-Mind is a 5-year project funded by Horizon 2020, with the goal of facilitating a paradigm shift in clinical practice of mild cognitive impairment. A team of Aalto University and HUS Helsinki University Hospital researchers are involved in the project. AI-Mind will create intelligent digital tools for screening of brain […]

Hormone therapy commonly is given as a targeted treatment for women whose cancer cells carry receptors for estrogen. But the therapy only works for about half of all patients. Until now, there hasn’t been a good way to reliably predict who will benefit and who will not. Researchers at Washington […]

Our pet dogs could help extend human lives beyond their documented effects on people’s wellbeing. Increasingly, studies are looking at how the domestic dog, Canis familiaris, is key to understanding cognition and processes involved in ageing – something that could improve both animal and human wellbeing. ‘In recent years, the […]

Working on a grant of £1.2 million donated by the Engineering and Physical Sciences Research Council (EPSRC) – a British Research Council that provides government funding to research projects related to the physical sciences – Professor Jonathan Shephard and his team are working on a new laser-based system for the […]

In trials these vaccines have shown to be at least 94% effective at preventing people from falling ill with Covid-19. But how safe is this new technology? We spoke to Michel Goldman, a professor of immunology and founder of the I3h Institute for Interdisciplinary Innovation in healthcare at the Université […]

What causes the immune system to err in this way is not clear, but a growing body of research is looking at the trillions of microbes that share our bodies, known collectively as the microbiome, for an answer. Studies of twins indicate that lifestyle, or environmental, factors can play a […]

A urine test based on University of Michigan Rogel Cancer Center research could have avoided one-third of unnecessary prostate cancer biopsies while failing to detect only a small number of cancers, according to a validation study that included more than 1,500 patients. The findings appear in the issue of the Journal of Urology. […]

Scientists in the Perelman School of Medicine at the University of Pennsylvania have uncovered the molecular causes of a congenital form of dilated cardiomyopathy (DCM), an often-fatal heart disorder. This inherited form of DCM — which affects at least several thousand people in the United States at any one time […]

A simple non-invasive test can accurately detect womb cancer according to a proof of concept study by University of Manchester and Manchester University NHS Foundation Trust (MFT) scientists. The non-invasive test, which detects cancer by looking at urine or vaginal sample with a microscope, could have a major benefit for patients if […]

Variants of nine genes increase the risk of developing Addison’s disease, a rare disease in which the immune system attacks the adrenal glands. That is according to the largest genetic study to date on patients with Addison’s disease. The findings help increase knowledge about what causes the disease. The study […]

Neuroblastoma arises within the sympathetic nervous system and is the most frequent extracranial solid childhood cancer, exhibiting a high degree of clinical heterogeneity ranging from spontaneous regression to fatal progression despite intense clinical intervention. Despite extensive sequencing efforts, the number of identified recurrent mutations remain low in pediatric neuroblastoma. Researchers […]

In people with Crohn’s disease, a chronic inflammatory bowel condition, symptoms or how they feel may not line up with actual inflammation in their gut. This mismatch creates challenges for accurately measuring how well a treatment is truly working, especially for children. Currently, many gastroenterologists use symptoms and blood tests […]

A research paper published in the New England Journal of Medicine has revealed that a new anti-obesity medication is almost twice as effective in helping people lose weight than other current weight loss drugs. Professor John Wilding, who leads clinical research into obesity, diabetes and endocrinology at the University of […]

Glycomics researchers at the University of Alberta and CHU Sainte-Justine have reported a discovery that could lead to new treatments for cardiovascular disease. The researchers identified a new mechanism responsible for the buildup of plaque on artery walls, a process known as atherosclerosis. This plaque, made up of fats, cholesterol […]

Genetics and multi-omic information could one day inform treatments for glioblastoma. The largest and most detailed molecular analysis yet of an aggressive brain cancer, called glioblastoma, reveals fundamental details that drive its growth. The work, led by a team of scientists from the U.S. Department of Energy’s (DOE) Pacific Northwest […]

Dance is considered as one of the art forms. Regardless of whether we do it professionally or as a hobby, it gives us great pleasure, relaxes, and allows us to break away from the prose of life. Thus, dance can be beneficial for our mind, memory, stimulation of the nerve […]

IMDEA Nanociencia researchers measure the nanoscale heating of gold-based nanoparticles and find high temperature variations within a nanoscopic volume. In hyperthermia treatments, the temperature is raised above physiological levels to induce the death of cancerous cells. The local application of hyperthermia is key for a successful treatment and to reduce […]

Researchers at the Garvan Institute of Medical Research have developed a computational model to calculate ‘skeletal age’, a personalised estimate of an individual’s risk of bone fracture and premature death. The skeletal age calculator, which will be accessible to doctors and health professionals, aims to better identify those at risk […]

Exposure to radiation can wreak indiscriminate havoc on cells, tissues, and organs. Curiously, however, some tissues are more vulnerable to radiation damage than others. Scientists have known these differences involve the protein p53, a well-studied tumour-suppressor protein that initiates a cell’s auto-destruct programs. Yet, levels of this sentinel protein are […]

NIH researchers take “deep dive” into brain’s transcriptome. A new study suggests that differences in the expression of gene transcripts – readouts copied from DNA that help maintain and build our cells – may hold the key to understanding how mental disorders with shared genetic risk factors result in different patterns […]