General

Scientists at the University of California, Irvine have developed a new deep-learning framework that predicts gene regulation at the single-cell level. Deep learning, a family of machine-learning methods based on artificial neural networks, has revolutionized applications such as image interpretation, natural language processing and autonomous driving. In a study published […]

The microbiome comprises trillions of microorganisms living on and inside each of us. Historically, some researchers have guessed at its role in human health, but in the last decade or so genetic sequencing techniques have illuminated this galaxy of microorganisms enough to study it in detail. As researchers unravel the […]

Michael Green, M.D., PhD, noticed that when his patients had cancer that spread to the liver, they fared poorly – more so than when cancer spread to other parts of the body. Not only that, but transformative immunotherapy treatments had little impact for this patient. Uncovering the reason and a […]

Researchers at Oregon State University have found that a few organisms in the gut microbiome play a key role in type 2 diabetes, opening the door to possible probiotic treatments for a serious metabolic disease affecting roughly one in 10 Americans. “Type 2 diabetes is in fact a global pandemic […]

The simple act of breathing is among the most familiar ways we convert nutrients to energy – inhaling molecules of oxygen and harmlessly breathing out unwanted material. But when our usual disposal mechanisms fail, the accumulated electrons can produce the kind of toxic event that causes many diseases, including cancer. […]

High blood pressure appears to accelerate a decline in cognitive performance in middle-aged and older adults, according to new research published today in Hypertension, an American Heart Association journal. Nearly half of American adults have high blood pressure or hypertension. Having high blood pressure is a risk factor for cognitive […]

A Washington state woman is recovering after a landmark organ transplant that she hopes will end her nearly decade-long bout with cancer. Kris Anderson, 51, of Redmond, received a lobe of liver from her daughter Lauren, 26, on Dec. 8. It was the Pacific Northwest’s first living-donor liver transplant for metastatic colorectal […]

Resveratrol and derived molecules were for a time excessively hyped as a means to trigger some of the beneficial metabolic response produced by calorie restriction, by acting on sirtuins, and thus have a positive impact on aging. The company Sirtris was founded to develop this area of research into a […]

Senolytic drugs are those capable of selectively destroying senescent cells. A range of such therapies are at various stages of development, including those that have reached initial human clinical trials. Senescent cell accumulation is an important cause of degenerative aging, and the removal of such cells via senolytic treatments has […]

Axin is a VIP – a Very Important Protein. It’s essential to the development of an embryo. It’s a key player in allowing the body’s cells to divide without going haywire and forming a tumour. It regulates the body’s production of lipids, or fats, which can affect aging. Essentially, it […]

The introduction of computer simulation to the identification of symptoms in children with attention-deficit/hyperactivity disorder (ADHD) has potential to provide an additional objective tool to gauge the presence and severity of behavioural problems, Ohio State University researchers suggest in a new publication. Most mental health disorders are diagnosed and treated based […]

In an in-depth study of how COVID-19 affects a patient’s brain, National Institutes of Health researchers consistently spotted hallmarks of damage caused by thinning and leaky brain blood vessels in tissue samples from patients who died shortly after contracting the disease. In addition, they saw no signs of SARS-CoV-2 in […]

Experiments with mice and humans showed that exercise training increased the expression in adipose tissue of a key enzyme for the organism's metabolic health, combating the harmful effects of aging and obesity. Adipose tissue is not just a simple reservoir of energy for periods of food scarcity. It contributes significantly […]

Women awaiting liver transplants in the United States are known to be about one-third more likely than men to become too ill to undergo surgery or die before receiving a liver. Now a study headed by UC San Francisco and Columbia University highlights the role that frailty plays in this […]

The human body is filled with friendly bacteria. However, some of these microorganisms, such as Veillonella parvula, may be too nice. These peaceful bacteria engage in a one-sided relationship with pathogen Porphyromonas gingivalis, helping the germ multiply and cause gum disease, according to a new University at Buffalo-led study. The […]

Small studies have suggested that a group of medications called RAS inhibitors may be harmful in persons with advanced chronic kidney disease, and physicians therefore often stop the treatment in such patients. Researchers at Karolinska Institutet now show that although stopping the treatment is linked to a lower risk of […]

In a new study led by the University of Washington School of Medicine, researchers demonstrate that SARS-CoV-2 – the pathogen behind COVID-19 disease – can enter the brain of mice, just like many other viruses before it. People who develop COVID-19 often experience intense bodily inflammation called a cytokine storm, […]

The authors of this open access papers discuss the prominent role of cell signaling in the better known classes of intervention that have been shown to slow aging in worms, flies, and mice. The body is a network in which cells in one tissue influence the behavior of cells in […]

Psoriasis, a chronic inflammatory skin disease, has long been known to increase the risk of cardiovascular disease, which includes heart attack and stroke. Now, researchers have identified a key culprit: the presence of metabolic syndrome (MetSyn), a condition that includes obesity, diabetes, high cholesterol, and hypertension, and is highly prevalent […]

When surgeons remove cancer, one of the first questions is, “Did they get it all?” Researchers from Rice University and the University of Texas MD Anderson Cancer Center have created a new microscope that can quickly and inexpensively image large tissue sections, potentially during surgery, to find the answer. The […]

Metolazone, a drug used to treat hypertension, activates a mitochondrial stress response that prolongs lifespan in the roundworm Caenorhabditis elegans A stress response of mitochondria, the part of our cells that produce energy to power bodily functions, is important to a longer life. A team of scientists from Osaka City […]

Baylor College of Medicine researcher Meng Wang had already shown that bacteria that make a metabolite called colanic acid (CA) could extend the lifespan of worms in her lab by as much as 50%, but her collaboration with Rice University synthetic biologist Jeffrey Tabor is providing tools to answer the bigger question of how […]

James Cook University’s Professor Edward Strivens and Associate Professor Sarah Russell from JCU’s Healthy Ageing Research Team have found were part of a group that examined 276 Torres Strait residents aged between 45 and 93. The study took in all 18 island and 5 mainland communities in the Torres Strait […]

Artificial intelligence is able to analyze vast amounts of information very quickly and efficiently. And, therefore, unsurprisingly it is very useful in medicine. Scientists from UCL and the Western Eye Hospital have now developed a new eye test, which takes advantage of AI technology to predict wet age-related macular degeneration […]

Type 2 diabetes is oftentimes called a lifestyle disease, because it is associated with obesity, poor levels of physical activity and a terrible diet. It can be prevented through lifestyle changes, but what are other options? A team of scientists led by the University of Adelaide conducted a 2 year […]

For the first time, scientists have recorded how our brains navigate physical space and keep track of others’ location. Researchers used a special backpack to wirelessly monitor the brain waves of epilepsy patients as each one walked around an empty room hunting for a hidden, two-foot spot. In an article […]

A new study from Tel Aviv University (TAU) presents an innovative treatment for deafness, based on the delivery of genetic material into the cells of the inner ear. The genetic material “replaces” the genetic defect and enables the cells to continue functioning normally. The scientists were able to prevent the gradual deterioration […]

Researchers at three Canadian universities find the key to unlocking the antidepressant effect of ketamine in the brain. A group of proteins called 4E-BPs involved in memory formation are key to unlocking the antidepressant effect of ketamine in the brain, according to a new study by researchers from three Canadian […]

UC San Francisco and BridgeBio Pharma, Inc. (NASDAQ: BBIO) today announced a partnership to drive the advancement of academic innovations in genetically driven diseases into potential therapeutics for patients. “The BridgeBio team is developing close relationships with our investigators at UCSF with the mission of bringing potential therapies into the […]

How genes get ‘switched on’ has fascinated scientists for decades, but equally important questions about how they are ‘turned off’ have been largely overlooked. As the messengers carrying instructions from DNA for the creation of proteins, the formation and decay of cellular RNAs is critical to maintaining cell stability and […]