General

Sophia Ceder and Klas Wiman and their colleagues at Department of Oncology-Pathology have together with researchers from Peter MacCallum Cancer Center, University of Melbourne, University of Cambridge and Aprea Therapeutics published a study in EMBO Molecular Medicine that provides novel understanding on the mechanisms of mutant p53 targeting compound APR-246. […]

For the first time, scientists at the University of Zurich have been able to observe stem cells in the adult mouse brain that divide over the course of several months to create new nerve cells. The study shows that brain stem cells are active over a long period, and thus […]

Here, researchers explore the mechanisms governing changes in cell behavior during reprogramming. Many of the aspects of aging found in cells taken from old tissues can be reversed via the process of reprogramming these cells into induced pluripotent stem cells. Mitochondrial function is restored to youthful levels, for example, as […]

University of Minnesota Twin Cities researchers in the Department of Chemistry have created a new polymer to deliver DNA and RNA-based therapies for diseases. For the first time in the industry, the researchers were able to see exactly how polymers interact with human cells when delivering medicines into the body. […]

Daniela Latorre wanted to be a scientist since she was a child. At the Institute for Research in Biomedicine, affiliated to the USI in Bellinzona and the Institute of Microbiology, she is finding evidence that narcolepsy is an autoimmune disease. She has now received the Pfizer Prize for Research 2020 […]

A new study, led by researchers at the University of Bristol and the International Agency for Research on Cancer (IARC), has revealed that where fat is on our body may lead to different health outcomes for men and women. The research, co-funded by World Cancer Research Fund (WCRF), Cancer Research […]

Individuals with high ADHD-traits that do not meet the criteria for a diagnosis are less able to perform tasks involving attentional regulation or emotional control after a sleepless night than individuals with low ADHD-traits, a new study from Karolinska Institutet published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging reports. While […]

The first study to compare molecular landscapes of early-onset and late-onset appendiceal cancer has revealed distinct non-silent mutations in the tumors of younger patients, setting the stage for the development of potential therapeutic advances for this rare disease. The findings, published in JAMA Network Open, were derived from an analysis […]

Scientists have revealed a mechanism that causes heart cells to age and identified a drug that can rejuvenate them, according to a study published in eLife.  The drug is now in clinical trials. The results provide the first direct evidence that aging increases proton leakage in heart cells. The findings […]

Senescent cell accumulation is an important cause of degenerative aging. Senescent cells cease replication and begin to secrete an inflammatory mix of signals that disrupt tissue structure and function. These cells are created constantly, largely as a result of somatic cells hitting the Hayflick limit on cellular replication, but also […]

A combination approach to treating a prevalent glioma subtype — including metabolic reprogramming, radiation, chemotherapy and immunotherapy — led to a complete regression of tumors in 60% of study mice, new research by the University of Michigan Rogel Cancer Center found. The findings, which appear in the Journal of Clinical Investigation, support the testing […]

Systemic sclerosis is an autoimmune disease associated with inflammation and fibrosis, or scarring, that affects organs including the skin, heart, kidney and lungs. This form of scleroderma, this tightening and thickening of the skin, is a progressive, orphan illness that affects approximately 80,000 Americans and has no clear pathogenesis or FDA […]

Chronic inflammation grows with age throughout the body, characterized by increased levels of numerous inflammatory signal molecules, among which is IL-6. One contributing factor to the chronic inflammation of aging is the accumulation of lingering senescent cells, which rouse the immune system via secreted molecules that include, prominently, IL-6. Researchers […]

Children who undergo cataract surgery as infants have a 22% risk of glaucoma 10 years later, whether or not they receive an intraocular lens implant. The findings come from the National Eye Institute (NEI)-funded Infant Aphakic Treatment Study, which today published 10-year follow-up results in JAMA Ophthalmology. NEI is part […]

Fractured sleep, daytime sleepiness and other signs of disturbance in one’s circadian rhythm are common complaints of people with Alzheimer’s disease, and the problems only get worse as the disease progresses. But the reason for the link between Alzheimer’s and circadian dysfunction is not well understood. Researchers at Washington University […]

Ribosomes are the machines in the cell that use instructions from mRNA to synthesize functional proteins. There are hundreds of thousands of ribosomes in each cell, and they mostly process their instructions faithfully. But sometimes ribosomes get stuck or stall on roadblocks along with defective mRNA molecules. New research from […]

Researchers here note a study population in which glucosamine use correlates with a reduction in mortality risk that is of a similar size to that associated with exercise. One always has the suspicion that, even after controlling for such things, the use of less common supplements is just a marker […]

University of Alberta researchers are among two Canadian research teams chosen for significant new funding from the Government of Canada and JDRF Canada to develop new stem cell-based therapies for treating Type 1 diabetes. The projects will each receive $1.5 million from the Canadian Institutes of Health Research Institute of Nutrition, Metabolism […]

Female COVID-19 patients face less severe disease complications and a lower risk of dying than male patients thanks to hormones and chromosomes that contribute to a stronger immune response, according to new research from a University of Alberta-led team. “The highlight of our study is how the sex differences in COVID-19 are […]

More and more evidence is coming out that people with COVID-19 are suffering from cognitive effects, such as brain fog and fatigue. And researchers are discovering why. The SARS-CoV-2 virus, like many viruses before it, is bad news for the brain. In a study published in Nature Neuroscience, researchers found […]

Mice, fruit flies and dogs are common creatures of laboratories across the country, valuable to researchers for their genetic proximity to humans. But what about lampreys? A new Yale School of Public Health study has enlisted this unlikely and slimy ally in the fight against cancer. By carefully tracing the […]

Autism spectrum disorder, estimated to affect one in 54 children in the United States, encompasses a range of complex neurodevelopmental conditions that typically emerge in the first few years of life. Yet for a variety of reasons, these conditions could be challenging to diagnose early when interventions are most likely to avert or […]

An increase of over 10% in the prevalence of hearing loss in the English over 50s may not be age-related, a new study by University of Manchester researchers has shown. Instead the study, published in BMC Geriatrics, found hearing loss could be linked to social and lifestyle differences in the north and […]

Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking place than was previously the case. In many cases it isn't all that clear […]

Targeting drugs to cancer tissues is a major challenge in cancer treatment. Mesenchymal stem cells (MSCs) are known for their ability to find and target tumor cells in the body, but using MSCs for drug delivery has been tricky, because upon loading with drugs, MSCs lose their viability and migratory […]

“The women were on average a decade older than men at the time of their first heart attack and they more commonly presented with the less severe type of heart attack,” said lead author Justin Ezekowitz, professor of medicine and co-director of the Canadian VIGOUR Centre. “But when they were faced with […]

Next-generation sequencing (NGS) has emerged as an important high throughput technology in biomedical research and translation for its ability to accurately capture genetic information. But choosing proper analysis methods for identifying biomarkers from high throughput data remains a critical challenge for most users. For instance, RNA-sequencing (RNA-seq) is an NGS […]

Georgetown University, Lawrence Livermore National Laboratory (LLNL) scientists and collaborators have identified a protein that when removed from the body may help pancreatic cancer patients live longer. Pancreatic cancer is one of the most lethal forms of the disease and has the lowest survival rate. Because the tumors are solid, many modern […]

Here, researchers note some of the challenges inherent in trying to analyze data on human inheritance of longevity; it isn't as easy as it sounds. Considerable effort has gone into analysis of long-lived families to try to identify genetic variants that might explain why some lineages exhibit greater longevity than […]

One of the more intriguing findings to emerge from study of the relationship between stress response mechanisms in cellular metabolism and the pace of degenerative aging is that evolution has not optimized for life span. Many aspects of metabolism can be adjusted in small ways – in mice, worms, flies, […]