General

As early as 1975, biologists discovered that the protein-coding parts of the chimpanzee and human genomes are more than 99 percent identical. Yet, chimpanzees and humans are clearly different in significant ways. Why? The answer lies in the fact that how DNA is used is as important as what it […]

Doctors and biostatisticians at the University of Michigan Rogel Cancer Center have led the development and validation of a staging system to better predict outcomes and inform treatment decisions for men diagnosed with non-metastatic prostate cancer. Although it is one of the most common cancers worldwide, prostate cancer remains one of the […]

An international team of researchers has identified a direct molecular link between meat and dairy diets and the development of antibodies in the blood that increase the chances of developing cancer. This connection may explain the high incidence of cancer among those who consume large amounts of dairy products and […]

Actin is among the most abundant proteins in cells, and it has many jobs—from giving the cell its very shape and structure to managing networks of proteins crucial to numerous cellular functions. Without it, the fragile fundamental unit of life would crumble. A good deal of actin’s activity is based […]

Imagine your young son has a rare disease that makes him susceptible to infections. If he catches the measles, will he be able to successfully fight it off? A researcher at Université de Montréal has discovered how to ensure he will: by getting him vaccinated. For people generally, vaccination is […]

University of Oregon biologists have used a model organism to identify molecular mechanisms that produce DNA damage in sperm and contribute to male infertility following exposure to heat. In humans, the optimal temperature for sperm production is just below body temperature, in a range of about 90-95 degrees F. Human […]

Researchers at Rice University and Baylor College of Medicine have developed a new method to isolate specific cells, and in the process found a more robust fluorescent protein. Both the platform and the protein could be highly useful to synthetic biologists and biomedical researchers. They often need to single out […]

The Alzheimer’s Biomarkers Consortium – Down Syndrome (ABC-DS), a multi-institution research team, co-led by members from the University of California, Irvine, has been awarded an unprecedented five-year, $109 million grant by the National Institutes of Health (NIH), to expand research on the biomarkers of Alzheimer’s disease in adults with Down syndrome. UCI principal investigators Elizabeth […]

Researchers at the University of Toronto have found evidence that neutrophil immune cell activity is the missing link connecting periodontal disease with heart disease, cancer and other inflammatory conditions – possibly including COVID-19. The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, […]

Humans are born with a part of the brain that is prewired to be receptive to seeing words and letters, setting the stage at birth for people to learn how to read, a new study suggests. Analyzing brain scans of newborns, researchers found that this part of the brain – […]

In a new study published in the journal Cell, Death & Differentiation researchers at Karolinska Institutet have conducted a translational study that identified a new mechanism for controlling the breakdown of glucose in several different cancer forms. The discovery could lead to new therapeutic strategies aimed to reduce cancer growth. […]

NIH-funded therapy will now be tested in humans. A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovation Research grant to […]

The prescription of potentially inappropriate medications to older adults is linked to increased hospitalizations, and it costs patients, on average, more than $450 per year, according to a new University at Buffalo study. The research, which sought to determine the impact of potentially inappropriate medications on health care utilization and […]

How life works may come down to dumbbell-like bits of DNA. Rice University scientists on a long quest to study the structure and function of chromosomes have found that amid the apparent chaotic state of DNA during interphase, when cells are between divisions, there are pockets of order in the configuration […]

For people with multiple sclerosis, a disease of the central nervous system, exercise is a proven way to hold off symptoms of fatigue and loss of mobility. But those same symptoms of the disease can cause such mobility issues in some people with MS that even getting started with exercising is […]

An electronic nudge to clinicians—triggered by an algorithm that used machine learning methods to flag patients with cancer who would most benefit from a conversation around end-of-life goals—tripled the rate of those discussions, according to a new prospective, randomized study of nearly 15,000 patients from Penn Medicine and published in […]

According to the Mayo Clinic, about 15% of couples are infertile, and male infertility plays a role in over one-third of these cases. Often, problems with sperm development are to blame. Now, researchers reporting in ACS Nano have found a way to deliver a protein important for sperm cell production directly to […]

For many cancers, doctors are increasingly looking to the DNA that solid tumours shed into the bloodstream to help with diagnosis and monitoring. But brain cancer has been a different story thanks to the natural blockade created by the blood-brain barrier. Researchers at the University of Michigan Rogel Cancer Center and Michigan Medicine […]

Brain cell dysfunction in low oxygen is, surprisingly, caused by the very same responder system that is intended to be protective, according to a newly published study by a team of researchers at Case Western Reserve University School of Medicine. “These powerful protein responders initially protect brain cells from low […]

Among women participating in cervical cancer screening in Sweden, those with a diagnosis of invasive cervical cancer had an increased risk of iatrogenic injuries (as a consequence of medical intervention) and non-iatrogenic injuries (caused by accidents and self-harm) requiring hospitalization, according to results published in Cancer Epidemiology, Biomarkers & Prevention. […]

Martin Enge’s research group at the Department of Oncology-Pathology has developed a new method for joint analysis of a cell’s state and accumulated genetic variation in single cells, applied to childhood leukaemias and other cancers. The article is published in the journal Molecular Cell. The method enables studies of how […]

A multidisciplinary team of researchers at McMaster University have discovered a structural feature of human bone that has never been studied before under a microscope, bringing scientists closer to advancing bone implants and treatments for bone diseases. Using a plasma focused ion beam microscope at the Canadian Centre for Electron […]

Ulcers are open wounds that fail to heal. They are caused or exacerbated by poor blood and nerve supply and in the case of foot ulcers, bad feet architecture. In severe cases, they can lead to amputation and there are an estimated 8,000 preventable foot amputations in Australia every year. […]

Researchers at McMaster and Brock universities have created the prototype for a hand-held device to measure a biomarker for cancer, paving the way for home-based cancer monitoring and to improve access to diagnostic testing. The device works much like the monitors that people with diabetes use to test their blood-sugar […]

New research shows a simple skin test can accurately identify Parkinson’s disease, demonstrating for the first time the feasibility of the method. Currently diagnosed by clinical signs and symptoms but only definitively diagnosed at autopsy, Parkinson’s disease is commonly misdiagnosed early in the disease course, complicating clinical trials of potential […]

Extracellular vesicles (EVs), nanometer-sized messengers that travel between cells to deliver cues and cargo, are promising tools for the next generation of therapies for everything from autoimmune and neurodegenerative diseases to cancer and tissue injuries. EVs have already been shown to help heart cells recover after a heart attack, but […]

This phase 2 trial also identified a subset of patients with specific mutations who may see the most benefit from the drug. When first- and second-line treatments have been exhausted, few options remain for patients with advanced head and neck cancer. A new phase 2 clinical trial by researchers at […]

Pharmaceutical maker Eli Lilly and Company have purchased Disarm Therapeutics, a startup biotechnology firm founded by researchers at Washington University School of Medicine in St. Louis. Disarm Therapeutics was co-founded by Jeffrey Milbrandt, MD, PhD, and Aaron DiAntonio, MD, PhD, to speed the development of treatments for multiple neurodegenerative conditions. Based […]

Intranasal administration of an anti-inflammatory drug helped reduce disease progression in a preclinical model of multiple sclerosis, according to recent research out of the University of Alberta. Christopher Power, a professor in the Faculty of Medicine & Dentistry, and Leina Saito, a graduate student on his team, showed that delivering an anti-inflammatory […]

New generation CRISPR technology lays foundation for therapeutics to treat a wide range of inherited ocular diseases. A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease. Published in Nature Biomedical […]