General

Researchers in the University of Toronto's Faculty of Applied Science & Engineering have discovered a dose threshold that greatly increases the delivery of cancer-fighting drugs into a tumour. The findings, published recently in the journal Nature Materials, provide a potentially universal method for gauging nanoparticle dosage and could help advance a new generation […]

A genetic diagnosis led to the successful treatment of a 52-year old man, guiding immune therapy for his rare cancer and providing relief after a lifetime of unexplained immune symptoms. Researchers led by A/Prof Tri Phan at the Garvan Institute of Medical Research, analyzed the genome of Sydney man Michael, […]

A research team of Prof. Bae Jee-hyeon of College of Pharmacy and Prof. Lee Kang-seok, Kim Keun-pil and Kim Han-yong of Department of Life Science has identified a molecular signaling mechanism that determines the repair pathways of DNA double-strand breaks (DSB) causing serious damage to genomes. The research results were […]

A team led by scientists from The University of Manchester has discovered how our genome controls the development of many of the organs critical to human life. The study, published in Nature Communications, casts crucial light on the little-understood stretches of DNA that sit between genes. The work will help scientists […]

Even after all of their symptoms are gone, people who have had a concussion take longer to regain complex reaction times, the kind you need in most real-life driving situations on the road, according to a preliminary study released today that will be presented at the American Academy of Neurology's […]

“Memory is the first thing to go.” Everyone has heard it, and decades of research studies seem to confirm it: While it may not always be the first sign of aging, some faculties, including memory, do get worse as people age. It may not be that straightforward. Zachariah Reagh, assistant […]

Discovering antiviral and anticancer drugs will soon be faster and cheaper thanks to new research from SFU chemist Robert Britton and his international team. For the past 50 years, scientists have used manmade, synthetic, nucleoside analogues to create drug therapies for diseases that involve the cellular division and/or the viral […]

Researchers at McMaster University and the Royal Ontario Museum (ROM) have reported  the discovery and diagnosis of an aggressive malignant bone cancer — an osteosarcoma — for the first time ever in a dinosaur. No malignant cancers—tumours that can spread throughout the body and have severe health implications—have ever been […]

Why do some people stay sharp into their 90s, even if they have the amyloid plaques in the brain that are associated with Alzheimer’s disease? And why do others reach their 90s without ever developing any plaques? These questions are explored in a new study published in the July 22, […]

A test that detects changing levels of tumour fragments in the blood may be an easy, non-invasive and quick way to predict who will benefit from immunotherapy, University of Toronto researchers say. Immunotherapy can shrink tumours and prolong survival for patients for whom other treatments have failed. But it only helps […]

A new type of immunotherapy for the skin cancer malignant melanoma shows promising results. Three severely ill patients are now long-term survivors. The study, published in OncoImmunology, is the result of a collaboration between researchers at Karolinska Institutet and Karolinska University Hospital. “Immunotherapy is based on activation of the body's […]

Aging is just not fun. At the later stages of your life you are more likely to encounter some serious health problems, such as Alzheimer’s disease. Once you hear this diagnosis, you know you’re in for a bad ending, because it is incurable. However, now scientists at the University of […]

Head and neck cancer is one of the leading causes of cancer-related deaths worldwide, and squamous cell carcinomas (HNSCC) account for the majority of these cases. In a new study, based on preclinical research and published in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research, researchers […]

Cancer immunotherapy — a treatment that better enables a patient’s own immune system to attack tumors — has shown great potential against some cancers. Yet immunotherapy doesn’t work against all tumor types, and many patients who initially respond later develop resistance and relapse. Researchers at University of California San Diego […]

From lowering your risk of obesity and cardiovascular disease to improving your concentration and overall daily performance, sleep has been proven to play a critical role in our health. In a new study, researchers at University of California San Diego School of Medicine report that sleep may also help people […]

Using stem cells to restore lost functions due to spinal cord injury (SCI) has long been an ambition of scientists and doctors. Nearly 18,000 people in the United States suffer SCIs each year, with another 294,000 persons living with an SCI, usually involving some degree of permanent paralysis or diminished […]

This open access paper expands on earlier work on cellular senescence in long-lived naked mole-rats. Individuals of this species can live as much as nine times longer than equivalently sized rodents, and are near immune to cancer. In other mammals, senescent cells accumulate with age and disrupt tissue function via […]

As of the past few years, the long-standing debate over whether moderate alcohol intake has a protective effect on health had appeared to resolve to the conclusion that the observed epidemiology is explained by socioeconomic factors, not by the metabolic effects of molecules such as polyphenols present in wine or […]

Infertility is a worldwide clinical problem for human health that affects 8 to 12 percent of couples. A new study from Washington University in St. Louis has implications for understanding some age-related aspects of male reproductive health in primates, including humans. Older male rhesus monkeys sire fewer offspring, even though […]

An analysis of a large study population here shows that glucosamine supplementation results in about a 15% reduction in mortality, a sizable effect size in the context of what is known of the effects of lifestyle choices and supplementation on aging. Glucosamine is used as an anti-inflammatory intervention, but there […]

A significant number of patients reported a deterioration in their hearing when questioned eight weeks after discharge from hospital admission for COVID-19, according to the University of Manchester audiologists, in a study supported by the NIHR Manchester Biomedical Research Centre (BRC). One hundred and twenty-one of the adults admitted to […]

More than three hundred years after Antonie van Leeuwenhoek used one of the earliest microscopes to describe human sperm as having a “tail, which, when swimming, lashes with a snakelike movement, like eels in water”, scientists have revealed this is an optical illusion. Using state-of-the-art 3D microscopy and mathematics, Dr Hermes […]

African-Americans have up to three times the risk of dying from strokes as people of European descent, yet there has been little investigation of if and how genetic variants contribute to their elevated risk. Until now. A large international team of scientists has completed the largest analysis of stroke-risk genes […]

Disruption of condensates in the neurodevelopmental disorder provides insights into how cells compartmentalize chromosomes, as well as new potential therapies. New discoveries about the disruption of condensates in the neurodevelopmental disorder Rett syndrome provide insights into how cells compartmentalize chromosomes, as well as new potential paths for therapies. Scientists have, […]

An international team led by UNSW medical researchers has tested a chemical compound in the lab and a range of animal models to progress much-needed treatment options for neovascular age-related macular degeneration (AMD) and diabetic retinopathy (DR), the main eye complication of diabetes. While the preclinical studies provide hope to […]

Researchers from JCU’s Queensland Research Centre for Peripheral Vascular Disease, involving collaborators from across Queensland, are conducting clinical trials to investigate whether a new drug can be used for treating blocked leg artery-related walking impairment. “People with blocked leg arteries have a substantially reduced ability to walk, which leads to […]

The multicellular, 3-D structure of human pancreatic islets — the areas of the pancreas containing hormone-producing or endocrine cells — has presented challenges to researchers as they study and manipulate these cells’ function, but Vanderbilt University Medical Center researchers have now developed a pseudoislet system that allows for much easier […]

A protein linked to amyotrophic lateral sclerosis (ALS), a progressive neurological disease that causes muscle weakness, may be a key to treating fibrotic disease of the kidneys and other organs, researchers at Vanderbilt University Medical Center reported recently. FUS is the acronym of a protein in the nucleus of cells that regulates […]

Many modern cancer drugs target a specific genetic mutation that is driving particular cancer’s runaway growth and division — such as the HER-2 protein in some breast cancers or EGFR in certain lung cancers. But this strategy hasn’t worked well against glioblastoma, an aggressive form of brain cancer, which is […]

The findings from a recent study by a University at Buffalo researcher and others could prove to be a game-changer for men with Type 2 diabetes. The single-site study, conducted over 11 years in Bremerhaven, Germany, found that testosterone therapy reversed Type 2 diabetes in one-third of the study participants. […]