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An off-label experiment in mice using disulfiram, which has been used to treat alcohol use disorder for more than 50 years, consistently normalized body weight and reversed metabolic damage in obese middle-aged mice of both sexes. The international study was led by researchers at the National Institute on Aging (NIA), […]

A new tool invented by the University of Alberta biologists to sequence circular DNA will provide scientists with richer, more accurate data that could help advance research on viruses, agriculture, and perhaps even cancer. The tool—called CIDER-Seq, which uses DNA sequencing technology called PacBio—was made available online by the U of […]

A large international trial has confirmed previous findings that a commonly used antidepressant is not effective in supporting the recovery of patients who have had a stroke. The results of the study, led by researchers from The University of Western Australia and The George Institute for Global Health in Sydney, were […]

Prostate cancer therapies have shown significant advances during the past decade, with multiple new therapies being introduced for patients with advanced disease. Now, the early results of a clinical trial published in the New England Journal of Medicine (NEJM) reveals for the first time that therapies based on tumor genetics – specifically DNA repair […]

Early results for a potentially revolutionary brain disease therapy given under compassionate use to a 2 year-old has shown promise, a University of Manchester scientist will tell an international conference. Professor Brian Bigger will tell the American Society of Gene & Cell Therapy that the safety and feasibility of the […]

A team of researchers from Harvard Medical School, Brigham and Women’s Hospital, Socios En Salud, and the Broad Institute at Harvard and MIT report they have identified the single largest genetic contributor to height known to date. The findings, published in Nature, are based on an analysis of samples from […]

For decades, the enormous disease-curing potential of human stem cells has been thwarted by the inability to produce sufficient quantities of mature human cells in vivo — in a living organism. Now, a team led by University at Buffalo scientists has developed a method that dramatically ramps up the production […]

Promising Research May Have Been Sullied by Shoddy Science. A protocol comprising dietary supplements and lifestyle changes that claim to prevent or reverse Alzheimer’s disease and cognitive decline has drawn media fanfare and critical acclaim from health gurus and even physicians. But the endorsement of these claims is frequently based […]

Even after successful antiretroviral therapy, HIV can hide dormant in a tiny number of immune system cells for decades and re-emerge to threaten the life of its host. Now Yale University researchers have discovered a molecular explanation for how the virus accomplishes this insidious trick, they report in the journal […]

A USC study found that a combination of a fasting-mimicking diet plus vitamin C delayed tumor progression and even caused disease regression in mice. Scientists from USC and the IFOM Cancer Institute in Milan have found that a fasting-mimicking diet could be more effective at treating some types of cancer when […]

An imbalance of unstable molecular species called ‘free radicals’ will change the colour of cells – and a new imaging technique could one day allow scientists to detect and decode this colour without needing to take samples from the body, a new study by UNSW Sydney researchers has found. The […]

Frequently, promising cancer therapies fail when applied to patients in the real clinical setting. This occurs despite many of these new treatments demonstrating promising results at the preclinical stage in the lab. One explanation is that many of the tumor models used in early research phases are established cell lines […]

Fatty food may feel like a friend during these troubled times, but new research suggests that eating just one meal high in saturated fat can hinder our ability to concentrate – not great news for people whose diets have gone south while they’re working at home during the COVID-19 pandemic. […]

Two in 10,000 people are at risk of serious sight loss from a form of eye inflammation known as uveitis. A new clinical research study, led by the University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust (UHBW), will evaluate a drug combination treatment for the eye […]

Whether we like it or not, our hair continually grows. Its regenerative powers reside deep inside each hair follicle, in a cluster of dividing stem cells—some of which will specialize and eventually give rise to new hair while others will produce new stem cells. Scientists have delineated numerous mechanisms that […]

Activating the G protein-coupled estrogen receptor (GPER) – a receptor found on the surface of many normal and cancer tissues – has been shown to stop pancreatic cancer from growing, but may also make tumors more visible to the immune system and thus more susceptible to modern immunotherapy. Researchers at […]

Researchers from McMaster University have found that the potato, primarily known as a starchy vegetable, can be a source of high-quality protein that helps to maintain muscle. The findings, reported in the journal Nutrients, highlight the potential benefits of what is considered a non-traditional source of protein, particularly as dietary […]

New imaging technology allows scientists to see the widespread loss of brain synapses in the early stages of Alzheimer’s disease, a finding that one day may help aid in drug development, according to a new Yale University study. The research, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s […]

UC Riverside-led study identifies role played by an immune signaling molecule in regulating memory function in the normal and injured brain. A study examining the effect of the immune receptor known as Toll-like Receptor 4, or TLR4, on how memory functions in both the normal and injured brain have found […]

New research show cells move and interact with each other in a way that is counter to what scientists have always believed. The study, published in the Journal of the Royal Society Interface shows that cell movement actually increases when there are more cells around. “We were quite surprised,” said Alex Browning, a […]

Growth hormone has been identified as playing a key role in reducing inflammation and increasing survival rates following liver surgery. Researchers at The University of Queensland Diamantina Institute investigated how the body’s growth hormone assists with liver regeneration in a study using mice. Project leader Dr Andrew Brooks said mice […]

Researchers have found that adult skates have the ability to spontaneously repair injured cartilage, using a type of cartilage stem cell. Human cartilage has very limited capacity for repair, and the finding may lead to new stem cell treatments for human cartilage injuries. Published in the journal eLife, the study […]

ETH researchers have developed a new method in which they use light to draw patterns of molecules that guide living cells. The approach allows for a closer look at the development of multicellular organisms – and in the future may even play a part in novel therapies. Highly complex organisms […]

Revealing the architecture of embryos at a crucial stage in development. The majority of pregnancies that fail do so at a very early developmental stage, before the pregnancy is even detectable by tests. This critical stage, occurring about a week after fertilization, is when an embryo implants itself into the […]

Subtle abnormalities occur in key brain structures of children diagnosed with the pediatric acute-onset neuropsychiatric syndrome, a disease characterized by abrupt, severe behavioral problems, according to a new study from the School of Medicine. The findings, reported in a paper published in JAMA Network Open, may help resolve an ongoing debate […]

Investigators at the School of Medicine and several other institutions have shown that a new type of vaccination can substantially enhance and sustain protection from HIV. A paper describing the vaccine, which was given to monkeys, was published online in Nature Medicine. The findings carry broad implications for immunologists pursuing vaccines for the […]

Researchers pinpoint genes behind sex biases in autoimmune disorders, schizophrenia. Some diseases exhibit a clear sex bias, occurring more often, hitting harder or eliciting different symptoms in men or women. For instance, the autoimmune conditions lupus and Sjögren's syndrome affect nine times more women than men, while schizophrenia affects more […]

Findings could lead to better methods for creating muscle cells from stem cells. An interdisciplinary team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA has developed a first-of-its-kind roadmap of how human skeletal muscle develops, including the formation of muscle […]

Already known for their shape-shifting abilities, stem cells can now add “death-defying” to their list of remarkable qualities. A new study shows how stem cells – which can contribute to creating many parts of the body, not just one organ or body part – are able to postpone their own […]

Repeats of individual building blocks within proteins are the cause of many hereditary diseases, but how such repeats actually cause disease is still largely unknown. Researchers in Berlin investigated how repeat elongations lead to the disease synpolydactyly, and have found that the attractive forces between the mutated proteins cause them […]