December 21, 2019

Hydration may affect cognitive function in some older adults

Not getting enough water is enough to make you feel sluggish and give you a headache, but a new Penn State study suggests it may also relate to cognitive performance. The researchers investigated whether hydration levels and water intake among older adults was related with their scores on several tests […]
December 20, 2019

Chimpanzees evolved to suppress pathogenicity of the precursor of HIV

Simian immunodeficiency virus, better known as SIV, is an HIV precursor. In other words, this  monkey- and ape-infecting virus is what HIV originated from. SIV attacks various monkeys, especially chimpanzees, but, interestingly, even infected animals are otherwise healthy. Why? Scientists from UCL say that some subspecies may have evolved a […]
December 20, 2019

Mothers’ and babies’ brains ‘more in tune’ when mother is happy

Mothers’ and babies’ brains can work together as a ‘mega-network’ by synchronising brain waves when they interact. The level of connectivity of the brain waves varies according to the mum’s emotional state: when mothers express more positive emotions their brain becomes much more strongly connected with their baby’s brain. This may help […]
December 20, 2019

Study: Healthy diet may avert nutritional problems in head, neck cancer patients

At least 90% of head and neck cancer patients develop symptoms that affect their ability or desire to eat, because of either the tumor itself or the surgery or radiation used to treat it. These problems, called nutrition impact symptoms, have wide-ranging negative effects on patients’ physical and mental health […]
December 20, 2019

Solving the puzzle of IgG4-related disease, the elusive autoimmune disorder

IgG4-related disease is an autoimmune disorder affecting millions and has no established cure. Previous research indicates that T cells, a major component of the immune system, and the immunoglobulin IgG4 itself are key causative factors, but the mechanism of action of these components is unclear. Now, Scientists from Tokyo University […]
December 20, 2019

Research reveals new drug target for autoimmune disease

Investigating a rare genetic immune condition has allowed researchers to uncover a new drug target for a range of autoimmune diseases, which affect one in eight individuals and currently have few therapeutic options. An international team, led by the Garvan Institute of Medical Research, discovered that the protein PI3K is […]
December 20, 2019

Breakthrough research offers new hope to lupus patients

A ‘life-changing’ potential new drug could be available to lupus patients in the future thanks to ‘breakthrough’ research. The results of the TULIP II study have been published in the New England Journal of Medicine (NEJM), one of the most prestigious, peer-reviewed medical journals in the world. TULIP stands for ‘Treatment […]
December 20, 2019

New study on liver humanized mice as a new model system for cholesterol lipoprotein metabolism and pharmacodynamics in humans

Researchers at Karolinska Institutet, together with colleagues from the EU-funded project HUMAN, recently published a study on a new animal model for studies of human lipoprotein metabolism and pharmacodynamics. The study is a result of the EU project HUMAN using a new animal model and new technologies to study aging […]
December 20, 2019

Glutamine may decrease obesity-linked inflammation

Glutamine could help people with obesity reduce inflammation of fat tissue and reduce fat mass, according to a new study at Karolinska Institutet in Sweden and the University of Oxford in the U.K. The researchers also show how glutamine levels can alter gene expression in several different cell types. However, […]
December 20, 2019

Fibroblasts Involved in Healing Spur Tumor Growth in Cancer

The connective tissue cells known as fibroblasts are vitally important for our recovery from injury. Sensing tissue damage, they gravitate to the site of a wound, instigating an inflammatory response that mends damaged tissue. A new Tel Aviv University study published in Nature Communications finds that fibroblasts also play a devastating role in the […]
December 20, 2019

A new role for a triple-negative breast cancer target

Unlike almost every other organ, the mammary gland does not develop until after birth. And it’s unusually dynamic, shape-shifting during menstrual cycles, puberty, pregnancy, and lactation. These changes require energy. In a study using a new, genetically altered mouse model, researchers led by Rumela Chakrabarti of Penn’s School of Veterinary Medicine have uncovered a key protein […]
December 20, 2019

Tackling Glioblastomas: Defeating a Deadly Foe

Each year, roughly 15,000 Americans are diagnosed with Glioblastoma Multiforme (GBM), the most common malignant primary brain tumor in adults… and also the most lethal. Surgery, radiation, and chemotherapy can help slow the tumor’s growth, but the disease remains incurable. Recurrence occurs in almost every case. But the tide to […]
December 20, 2019

Comparing heirloom and modern wheat effects on gut health

Amid concerns about gluten sensitivity, increasing numbers of people are avoiding wheat. Most have not been diagnosed with a wheat-related medical condition, yet they seem to feel better when they don’t eat gluten-containing foods. A possible explanation is that modern varieties of wheat are responsible. But now, researchers reporting in […]
December 20, 2019

Saccharin derivatives give cancer cells a not-so-sweet surprise

Saccharin received a bad rap after studies in the 1970s linked consumption of large amounts of the artificial sweetener to bladder cancer in laboratory rats. Later, research revealed that these findings were not relevant to people. And in a complete turnabout, recent studies indicate that saccharin can actually kill human […]
December 20, 2019

Study may explain how infections reduce autism symptoms

For many years, some parents have noticed that their autistic children’s behavioral symptoms diminished when they had a fever. This phenomenon has been documented in at least two large-scale studies over the past 15 years, but it was unclear why fever would have such an effect. A new study from […]
December 20, 2019

Why Your First Battle With Flu Matters Most?

The first strain of influenza virus we encounter during childhood sets the course of how our immune system responds to exposures later in life. How successfully a person can fend off the flu depends not only on the virus' notorious ability to change with the season, but also on the […]
December 19, 2019

A way to ‘fingerprint’ human cells

Researchers say a new method to analyse data from individual human cells could be a step-change for diagnosing some of the most devastating diseases, including cancer and autoimmune disease. By combining single cell analysis techniques with machine learning algorithms, a team led by researchers at the Garvan Institute of Medical […]
December 19, 2019

Researchers support new strategies for HIV control

The search for a cure to AIDS has partly focused on ways to eradicate infected cells. Now, new research from Karolinska Institutet in Sweden and the University of Pennsylvania in the U.S. shows that this approach may not be necessary for a functional cure. In a study focusing on a […]
December 19, 2019

Cracking the Fever-Autism Mystery

For many years, the parents of children with autism have reported that behavioral symptoms diminished when the child had a fever. The fever phenomenon has been documented in at least two large-scale studies over the past 15 years, but the reasons behind it have continued to mystify scientists. Now, a […]
December 19, 2019

Children with HIV score below HIV-negative peers in cognitive, motor function tests

Children who acquired HIV in utero or during birth or breastfeeding did not perform as well as their peers who do not have HIV on tests measuring cognitive ability, motor function and attention, according to a report published online in Clinical Infectious Diseases. The observational study included neuropsychological evaluations of 611 […]
December 19, 2019

Researchers discover a new mechanism in childhood kidney cancer

As an embryo develops, its cells must learn what to do with the thousands of genes they’ve been equipped with. That’s why each cell comes with a detailed gene-expression manual outlining exactly which genes should be switched on, to what extent, and when. To execute their respective manuals, the cells […]
December 19, 2019

Researchers Uncover Defective Sperm Epigenome that Leads to Male Infertility

Male Infertility New mouse model allows researchers to track defective sperm and potentially find ways to correct it. One out of eight couples has trouble conceiving, with nearly a quarter of those cases caused by unexplained male infertility. For the past decade, research has linked that infertility to defective sperm […]
December 19, 2019

Forgetfulness might depend on time of day

Can’t remember something? Try waiting until later in the day. Researchers have identified a gene in mice that seems to influence memory recall at different times of day and tracked how it causes mice to be more forgetful just before they normally wake up. “We may have identified the first […]
December 19, 2019

E-Cigarettes Significantly Raise Risk of Chronic Lung Disease, First Long-Term Study Finds

E-cigarette use significantly increases a person’s risk of developing chronic lung diseases like asthma, bronchitis, emphysema or chronic obstructive pulmonary disease, according to new UC San Francisco research, the first longitudinal study linking e-cigarettes to respiratory illness in a sample representative of the entire U.S. adult population. The study also […]
December 19, 2019

Using knowledge of gut bacteria to improve stem cell transplantations

In recent years, researchers all over the world have been seeking a deeper understanding about the impact of people’s gut bacteria—their so-called microbiome—on their health and risk of developing different diseases. Researchers from the National Food Institute, Technical University of Denmark (DTU), in cooperation with Rigshospitalet, have investigated the microbiome […]
December 19, 2019

Origin story: Rewriting human history through our DNA

For most of our evolutionary history — for most of the time anatomically modern humans have been on Earth — we’ve shared the planet with other species of humans. It’s only been in the last 30,000 years, the mere blink of an evolutionary eye, that modern humans have occupied the […]
December 19, 2019

When cells cycle fast, cancer gets a jumpstart

The progression of cancer has been studied extensively, and the key steps in this journey have been well mapped, at least in some solid tumors: Lesions to genes that confer risk of cancer accumulate and alter normal cell behaviors, giving rise, scientists believe, to early-stage cancer cells that eventually swamp […]
December 18, 2019

Skin Cancer Mystery Revealed in Yin and Yang Protein

It starts off small, just a skin blemish. The most common moles stay just that way — harmless clusters of skin cells called melanocytes, which give us pigment. In rare cases, what begins as a mole can turn into melanoma, the most serious type of human skin cancer because it […]