General

Researchers from the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Jonsson Comprehensive Cancer Center have discovered an important distinction in how blood-forming stem cells are supported by their micro-environments during rest and after injury. The body appears to switch the type of cell that produces […]

Scientists now have the ability to label cell parts in bright fluorescent colors, render tissue slices in high-definition photos and use video to monitor animal behavior down to the milliseconds. After capturing such images, researchers can analyze them to gain new insights on everything from basic cell structure to cancer […]

About 50 percent of people who reach the age of 85 will develop Alzheimer’s disease. Most will die within about five years of exhibiting the hallmark symptoms of the disease – severe memory loss and a precipitous decline in cognitive function. But the molecular processes that lead to the disease […]

Researchers have developed a new form of nanoparticle and associated imaging technique that can detect multiple disease biomarkers, including those for breast cancer, found in deep-tissue in the body. Reported in the science journal ‘Nature Nanotechnology’, the research opens up a new avenue in minimally invasive disease diagnosis and will […]

The rarity of appendix cancer, accounting for less than 1 percent of tumors that originate in the gastrointestinal tract, and the lack of scientific data for this disease means that current treatment guidelines recommend applying therapies to people with appendix cancer that are intended for those with colon cancer. To […]

The bladder is a master at self-repair. When damaged by infection or injury, the organ can mend itself quickly, calling upon specialized cells in its lining to repair tissue and restore a barrier against harmful materials concentrated in urine. But a new study in mice from researchers at the University […]

In a study published in Aging Cell, researchers at the University of Wisconsin–Madison show that mice making too much of a human protein called AT-1 show signs of early aging and premature death, which are also symptoms of the human disorder progeria. Researchers were able to reverse the signs of accelerated […]

MIT chemical engineers have developed a new sensor that lets them see inside cancer cells and determine whether the cells are responding to a particular type of chemotherapy drug. The sensors, which detect hydrogen peroxide inside human cells, could help researchers identify new cancer drugs that boost levels of hydrogen […]

The fusion of a sperm cell with an egg cell is the very first step in the process that leads to new individuals in sexually reproducing species. Fundamental as this process may be, scientists are only now beginning to understand the complexities of how it works. In a paper published […]

Researchers at University of California San Diego School of Medicine report that they have successfully created spinal cord neural stem cells (NSCs) from human pluripotent stem cells (hPSCs) that differentiate into a diverse population of cells capable of dispersing throughout the spinal cord and can be maintained for long periods […]

A koala virus could help researchers explain millions of years of accumulated ‘junk’ DNA in the human genome. An international team of researchers – including scientists from The University of Queensland – is studying a virus infecting koalas in the hope it could demonstrate how viruses have altered the DNA […]

When Joan Jorgensen was an undergraduate at the University of Wisconsin–Madison, her roommate confided that she had just one period before going through menopause in high school. Doctors told Jorgensen’s roommate that she would never have biological children. “This is devastating news at any age, let alone a high school […]

In the treatment of cancer, chemotherapy is a cleaver, not a scalpel. By attacking rapidly dividing cells, chemotherapy effectively fights tumors, but it also ravages healthy cells in the gut, bone marrow, the scalp and other organs, leading to severe side effects. These toxic chemicals save lives, but at a […]

Hookworms infect nearly 430 million people in the world, mostly in countries where sanitation is poor, and people often walk barefoot. The body’s immune system is critical to attacking the hookworm, resulting in damage to the body’s tissues. But just how this damage takes place — and what helps repair […]

Key aspects of the ageing of human cells can be reversed by new compounds developed at the University of Exeter, research shows. In a laboratory study of endothelial cells – which line the inside of blood vessels – researchers tested compounds designed to target mitochondria (the “power stations” of cells). In […]

A correlation between obesity and genetics has been found to be modified by diet, according to a scientific paper in the American Journal of Clinical Nutrition. A research group led by a U.S. Department of Agriculture (USDA) scientist found that a specific gene—APOA2—can result in a higher body mass index (BMI). […]

A University of Adelaide scientist and leading Adelaide surgeon is developing an early detection test for a deadly cancer and has today received a funding boost from the Ovarian Cancer Research Foundation (OCRF). Professor Martin Oehler, Clinical Professor of Obstetrics and Gynaecology at the University’s Robinson Research Institute and Director of Gynaecological […]

Symptoms of Parkinson’s disease include tremor, loss of smell and neuropsychiatric problems. However, many people aren’t diagnosed until their disease is well-advanced, which could limit their treatment options. Now, researchers have tested a sensor to detect early-stage Parkinson’s disease from the breath of patients. They report their results in ACS Chemical […]

A new genetic screen may predict a person’s future risk of osteoporosis and bone fracture, according to a study by a researcher at the Stanford University School of Medicine. Specifically, the study, one of the largest of its kind, identified 899 regions in the human genome associated with low bone-mineral density, […]

A pair of new studies led by investigators at Harvard Medical School and Boston Children’s Hospital looks to T cells as paths toward reducing organ transplant rejection and treating autoimmune diseases. The immune system has two major kinds of T cells. T helper cells, also known as effector T cells, […]

Mutations in the gene LRRK2 have been linked to about three percent of Parkinson’s disease cases. Researchers have now found evidence that the activity of LRRK2 protein might be affected in many more patients with Parkinson’s disease, even when the LRRK2 gene itself is not mutated. The study was published […]

Throughout his science training in Vietnam, Germany, Austria and the United States, Nam Chu has loved finding ways to fight diseases such as neurodegeneration and cancer. “To do that,” he says, “you need to understand the underlying molecular mechanisms—how certain proteins can cause the disease and how you can intervene.” Now a […]

A gene linked to 3 to 4 percent of people with Parkinson’s disease could play an important role in most, if not all, people with the disease, according to new study findings from the University of Pittsburgh School of Medicine and UPMC. The gene, called LLRK2, was previously thought to only cause […]

A wildebeest knows when it is outnumbered by a pack of hungry hyenas, thanks to an imprecise, primal brain function called the Approximate Number System, or ANS. Animals have it and human babies are born with it. Scientists have long believed that human’s ability to solve symbolic math problems such […]

It is summer now and we are all rushing to the nearest beach, river or lake. It helps us to cool down, but we can also try some extreme sports there, such as jumping to the water from some height. That can result in some injury and as a new […]

Convelo Therapeutics Inc., a company founded on seminal scientific discoveries made in the laboratories of Paul Tesar and Drew Adams at Case Western Reserve University School of Medicine, has launched from working in stealth mode with a mission to discover and develop a new class of medicines that regenerate the […]

The immune system can be an important ally in the fight against cancer. A study from McGill scientists published today in Science suggests that the reverse may also be true – that abnormal inflammation triggered by the immune system may underlie the development of stomach tumours in patients with a hereditary cancer syndrome known […]

Genes produce proteins that keep your body functioning and healthy. But genes that code for protein make up less than 2 percent of your DNA. The rest of the DNA might appear to be dormant at first glance, but scientists now appreciate that this region plays a key role in […]

The lack of certain toxic and cancer-causing chemicals in e-cigarettes may not necessarily mean that e-cigarette users are not exposed to them anyway. A new study from the University of Minnesota found that while e-cigarettes contain virtually no N-nitrosonornicotine (NNN) — a chemical that can cause oral cavity and esophageal cancer […]

UA students study honey bees to find out how bacteria in their guts and the foods they eat are connected to life expectancy. They hope the insects can serve as model systems to discover clues about how genetics, gut bacteria and diet influence aging in humans. To the untrained eye […]