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An improved intracellular delivery system that can carry revolutionary gene-editing tools to stem cells, potentially curing diseases with genetic causes A method to increase prospects of successful births for couples undergoing in vitro fertilization, which currently fails 67 percent of the time The possibility that an effective drug treatment can […]

MIT biologists have designed a new peptide that can disrupt a key protein that many types of cancers, including some forms of lymphoma, leukemia, and breast cancer, need to survive. The new peptide targets a protein called Mcl-1, which helps cancer cells avoid the cellular suicide that is usually induced […]

A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells. There is a critical need to non-invasively and remotely manipulate cells at a distance, particularly for translational applications in animals […]

The first three-dimensional structure of DHHC proteins — enzymes involved in many cellular processes, including cancer — explains how they function and may offer a blueprint for designing therapeutic drugs. Researchers have proposed blocking DHHC activity to boost the effectiveness of first-line treatments against common forms of lung and breast […]

Immunotherapies are promising in theory, but often not in practice. In fact according to experts, they actually only work 10 percent of the time in the treatment of cancer – at best. Yet, while immunotherapy drugs may only help a minority of patients, those who do respond often do extremely well. […]

A team of cancer researchers from the University, has made an important contribution to our understanding of cancer cell regulation which could better inform future cancer treatments. The research is funded by North West Cancer Research, which has ring-fenced £180,000 for the three year-long project which started in 2015. Led by Professor […]

Few cancer treatments are generating more excitement these days than immunotherapy—drugs based on the principle that the immune system can be harnessed to detect and kill cancer cells, much in the same way that it goes after infectious microorganisms. Yet these treatments only benefit some patients, and remain ineffective in […]

Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury – and getting them to stay there – remains challenging. In a new pilot study using an animal model, North Carolina State University researcher Ke Cheng and his […]

When you receive a vaccine against a disease like polio or influenza, your immune system gears up to defend against that particular infection. If you wind up getting chickenpox instead, or even a slightly different strain of the flu, you would be out of luck. That’s because traditional vaccines enlist […]

An international team, led by researchers at the University of California San Diego School of Medicine, has developed and validated a genetic tool for predicting age of onset of aggressive prostate cancer, a disease that kills more than 26,000 American men annually. The tool, described in the journal BMJ (formerly the British Medical […]

After treatment, young women diagnosed with breast cancer who carry a BRCA mutation have the same chances of survival as women without the mutation, according to a prospective cohort study led by the University of Southampton. BRCA mutations occur in either the BRCA1 or BRCA2 gene, and are inherited. These […]

What if we could diagnose early-stage Alzheimer’s disease (AD) by looking into a person’s eyes? A retinal scan technique, developed by researchers in the University’s Center for Drug Design (CDD), has the potential to detect AD in its early stages, when treatment may still be possible, and also to allow […]

Rice University bioscientist Aryeh Warmflash has won a major National Institutes of Health grant to analyze a protein-signaling pathway that directs the differentiation of embryonic stem cells into the cells of the skin and the nervous system. The work will build upon Warmflash’s research into human embryonic development and the mechanisms by which nearly […]

Everyone wants to be strong and young as long as possible. However, with old age comes frailty. Are there any ways to defeat it? Scientists from UCL say that diet is a good way. A new research revealed that a Mediterranean diet that is rich in fruits, vegetables, whole grains […]

We can not influence what has been, but we have a real opportunity to change what awaits us. 3D printing technology is already revolutionizing the world, and this is just the beginning. Aging is an inseparable element of every human existence, regardless of skin color, sex or place of residence. […]

Many women struggling to have a baby turn to in-vitro fertilization to improve their chances, and then face further uncertainty and anxiety when confronted with the decision of whether to use frozen or fresh embryos. A new study by a researcher at Yale School of Public Health and co-authors in […]

Researchers at the Case Comprehensive Cancer Center (CCCC) at Case Western Reserve University have helped develop a computer program to find new indications for old drugs. The computer program, called DrugPredict, matches existing data about FDA-approved drugs to diseases, and predicts potential drug efficacy. In a recent study published in Oncogene, the […]

Attempts to eradicate cancer are often compared to a “moonshot” — the successful effort that sent the first astronauts to the moon. But imagine if, instead of Newton's second law of motion, which describes the relationship between an object's mass and the amount of force needed to accelerate it, we […]

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons — the cells that give us our sense of touch. The new protocol could be a step toward stem cell–based therapies to […]

In the nervous system, a synapse is the place where signals are passed from neuron to neuron. The recently published paper focuses on synaptic dysfunction and its impact on dementia severity and cognition in the elderly with various dementia diagnoses. In addition to Alzheimer´s disease, the Lewy body dementias are the […]

New national research led by Jonathan Lass of Case Western Reserve University School of Medicine has found that corneal donor tissue can be safely stored for 11 days before transplantation surgery to correct eye problems in people with diseases of the cornea. This is four days longer than the current […]

Why does immunotherapy achieve dramatic results in some cancer patients but doesn’t help others? It is an urgent and vexing question for many cancer specialists. Now, two research groups from Harvard Medical School based at Dana-Farber Cancer Institute have independently discovered a genetic mechanism in cancer cells that influences whether […]

University of Alberta researchers have discovered a mechanism that may make cancer cells more susceptible to treatment. Post-doctoral fellow Mohammad Ali and his research team found that the protein RYBP prevents DNA repair in cancer cells, including breast cancer, which in turn could make chemo or radiation therapy more effective. […]

While refining ways to grow arterial endothelial cells in the lab, a regenerative biology team at the Morgridge Institute for Research at the University of Wisconsin–Madison unexpectedly unearthed a powerful new model for studying a hallmark of vascular disease. The team, led by Morgridge Institute Fellow Dave Vereide, describes in the Jan. 9, […]

Research at Virginia Tech and Penn State that has revealed how a parasitic plant utilizes cross-species gene manipulation to attack its victims could lead to a method to engineer parasite-resistant plants. Dodder, a parasitic plant that damages millions of dollars' worth of crops each year, is a stealthy invader that […]

One of the most puzzling questions in breast cancer research is why some tumors stay put, while rogue cells from others break free and spread to surrounding tissues, the first step toward creating a more lethal disease. Although researchers have found some signs in mutated genes or telltale proteins on […]

Cancer cells can be destroyed more effectively and selectively with a unique new reusable treatment, activated with a substance found in stinging nettles and ants – thanks to new research by the University of Warwick.  Cancer cells killed more effectively and selectively with a new approach, using a substance found […]

One of the most widely used drugs to fight cancer could become more effective and safer, based on findings emerging from the lab of UO chemist Vickie DeRose. In two recently published papers, separate projects using different approaches and led by two of DeRose’s doctoral students have made new predictions for […]

A type of soil-dwelling bacterium produces molecules that induce death in melanoma cells, research at Oregon State University shows. The molecule is a secondary metabolite, also known as a natural product, of Streptomyces bottropensis, and its properties are important because there are not many therapies that effectively manage melanoma, the […]

An old drug supercharged by University of Queensland researchers has emerged as a new antibiotic that could destroy some of the world’s most dangerous superbugs. The supercharge technique , led by Dr Mark Blaskovich and Professor Matt Cooper from UQ’s Institute for Molecular Bioscience (IMB), potentially could revitalise other antibiotics. Antibiotic-resistant bacteria […]