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Recently, neurobiologists from Leipzig and Würzburg universities investigated that a gene mutation that causes blindness is also associated with increased verbal IQ and working memory. Thus far, it was unclear how the mutation affects synaptic function. Scientists used CRISPR/Cas9-assisted genomic engineering to insert patients’ mutations into the corresponding gene in […]

In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system activity. In a new study, researchers from the Institut Pasteur, INSERM(1) and Université Paris Cité describe the mechanisms that modify the […]

Salk scientists improve liver regeneration in mice, which could lead to new treatments for liver disease Mammals can’t typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, Salk scientists have found a way to partially reset liver cells to more youthful states—allowing them to heal […]

Gut microbiota by-products circulate in the bloodstream, regulating host physiological processes including immunity, metabolism and brain functions. Scientists from the Institut Pasteur (a partner research organization of Université Paris Cité), Inserm and the CNRS have discovered that hypothalamic neurons in an animal model directly detect variations in bacterial activity and […]