General

Mutations affecting growth hormone metabolism and insulin metabolism, and that lead to extended life, are comparatively well studied in mammals. The longest lived mice are those in which growth hormone receptor is knocked out. Unfortunately, this, like many interventions related to growth, nutrient sensing, and the like, produces a much […]

The practice of calorie restriction improves long-term health and slows near all aspects of aging assessed to date. In humans, the beneficial effects of calorie restriction on healthy people are larger than any enhancement technology is yet proven to supply; it remains to be seen as to how the first […]

A good deal of evidence points to declining kidney function as a cause of declining cognitive function in aging. There are strong correlations between loss of kidney function and risk of dementia, for example. Correlation isn't a smoking gun in matters of aging, however: it is possible for any one […]

Why hasn't the research and development community achieved greater progress towards solving the problem of hair loss with age, given the sizable interest in achieving this goal? One possible answer is that a hair follicle is a very complicated structure that undertakes a shifting pattern of behaviors over time. It […]

Enforced retirement is a great iniquity, in those countries where it exists. This is true of any attempt by the powers that be to thrust their idea of how a life should be lived onto tens of millions of people, all capable of making their own choices. Progress in medicine […]