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Researchers have in recent years put forward contradictory evidence for and against a role for persistent infection, such as by herpesviruses, in neurodegeneration and the incidence of Alzheimer's disease. The Alzheimer's disease scientific community is in need of a good explanation as to why only some people with the known […]

The aging of the vasculature has detrimental effects on organs throughout the body. The most structurally apparent issue is that of atherosclerosis, the buildup of fatty deposits that narrow and weaken blood vessels. This ultimately leads to heart failure, stroke, heart attack, and death. A close second is the stiffening […]

Insilico Medicine announces the preclinical candidate for kidney fibrosis discovered using end-to-end artificial intelligence engine. Insilico Medicine, a global company specializing in the applications of the next-generation machine learning technologies for drug discovery and development, announced today that its AI-powered drug discovery platform had delivered the preclinical candidate (“PCC”) for […]

Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor. The interrupted non-coding regions in pre-mRNAs, termed “introns,” are excised by “splicing” to generate mature coding mRNAs that are translated into proteins. As human pre-mRNA introns vary in length, the […]

We have only one way to come out of this pandemic – vaccines. And yet many people are hesitant to take them, because of myths, anxiety, distrust of the pharmaceutical industry and actual cases of vaccine-induced immune thrombocytopenia and thrombosis. Now scientists from UCL have a better understanding of the […]

Cells become senescent in response to potentially cancer-inducing stresses and damage, to tissue injury, or when they reach the Hayflick limit on cellular replication. Senescent cells cease to replicate and secrete pro-inflammatory, pro-growth signals. They are cleared by the immune system or via programmed cell death mechanisms. Their presence is […]

This open access paper discusses a secondary issue in the aging of the adaptive immune system. Of primary concern is that the supply of new T cells diminishes over time, due to the atrophy of the thymus where such cells mature, as well as due to issues in the hematopoietic […]