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Over the past two decades, targeted cancer therapies have changed the prognosis for thousands of patients. By targeting the specific genetic mutation behind a patient’s cancer, these therapies have enabled increasing numbers of patients to experience fewer toxic side effects and, often, live free of disease following their treatment. But […]

Acrylamide, which is extensively used in industries, causes peripheral neuropathy or encephalopathy. Now, scientists from Japan examined the response against oxidative stress in acrylamide-induced neurotoxicity and found that nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of the immune system and response to oxidative stress, was at the […]

Regenerative medicine researchers have made progress toward overcoming a seemingly intractable obstacle to stem cell-derived heart cell transplantation for repairing damaged heart muscle. Their approach is a significant advance toward making heart cell transplants a potential reality for patients with cardiac disease. Their findings were presented at the International Society for Stem […]

New study challenges long-standing assumptions about disease severity in infants. Pertussis, also known as whooping cough, remains a significant cause of death in infants and young children around the world and, despite global vaccination programs, many countries are experiencing a resurgence of this highly contagious disease. A new study by Boston […]

Articular cartilage is a connective tissue lining the surfaces of joints. When the cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that affects millions of people globally. The articular cartilage is composed of a dense extracellular matrix (ECM) with a sparse distribution of cells found in healthy […]

If the genome is the recipe of life, base pairs are the individual ingredients listed. These chemical structures form DNA, and every living organism on Earth has just four. The specific arrangements of these four base pairs — A, T, C, G — make us who and what we are. […]

The gut and the brain communicate with each other in order to adapt satiety and blood sugar levels during food consumption. The vagus nerve is an important communicator between these two organs. Researchers from the Max Planck Institute for Metabolism Research in Cologne, the Cluster of Excellence for Ageing Research […]

A hydrogel that forms a barrier to keep heart tissue from adhering to surrounding tissue after surgery was developed and successfully tested in rodents by a team of University of California San Diego researchers. The team of engineers, scientists and physicians also conducted a pilot study on porcine hearts, with […]

Neutrophils belong to the first responders of our immune system. They circulate in our bodies and hunt in infected tissues to ingest, kill, and digest harmful pathogens. To become such effective killers in the very complex situation of an inflamed tissue, they work together as a collective. They release chemical […]

Many diseases caused by a dysregulated immune system, such as allergies, asthma and autoimmunity, can be traced back to events in the first few months after birth. To date, the mechanisms behind the development of the immune system have not been fully understood. Now, researchers at Karolinska Institutet show a […]

A noted diabetes researcher and public health advocate from the University of Toronto has been selected to lead a “powerhouse” research network that will focus on the global fight against diabetes and other serious chronic diseases. Lorraine Lipscombe, a physician and associate professor in the department of medicine in the […]

Case Western Reserve University researchers studying prions—misfolded proteins that cause lethal incurable diseases—have identified for the first time surface features of human prions responsible for their replication in the brain. The ultimate goal of the research is to help design a strategy to stop prion disease in humans—and, ultimately, to […]

University of Utah Health scientists and collaborators with the Adolescent Brain Cognitive Development (ABCD) Consortium have developed a rich resource for studying how the brain changes and matures during adolescence: a collection of functional MRI scans revealed patterns of brain activity in more than 6,000 9- and 10-year-old children. The […]

Evolution is hardly predictable. But it works. And works so well, that this efficiency of evolving is often underestimated by a large part of scientific community. Quick fact: in less than two weeks bacteria can evolve to resist antibiotics thousands of times stronger than what would have killed them at […]

A large international study on the effects of cooling the brain after a cardiac arrest shows that contrary to current treatment recommendations, it doesn’t actually improve survival or recovery. The study, published in the New England Journal of Medicine, suggests that a less intensive approach to temperature control in these patients […]

Christina often struggled to get through the average day. A former teacher diagnosed with treatment-resistant depression – along with OCD, bipolar disorder and Complex Post-Traumatic Stress Disorder (CPTSD) – was unable to work. At one point she was taking almost 60 different pills per day, with little to no effect […]

Altering traumatic memories in a way that eases their burden could be the key to treating survivors of post-traumatic stress disorder and other anxiety disorders, according to one of the University of Alberta’s newest Canada Research Chairs (CRC). Peggy St. Jacques, the psychology researcher in the Faculty of Science and CRC in […]

The B.1.1.7 coronavirus variant—also known as Alpha—may be more infectious because it contains mutations that make it better adapted to foil the innate immune system, at least for long enough to allow the virus to replicate and potentially find new hosts, according to a new study on BioRxiv. In the study, […]

New research published challenges a popular belief that intermittent fasting diets such as alternate day fasting or the ‘5:2’ are the most effective ways to lose weight. Over recent years, diets that see people fast on a few days each week have increased in popularity, reinforced by images of people’s […]

Researchers at Karolinska Institutet found industrial chemicals in the organs of fetuses conceived decades after many countries had banned the substances. In a study published in the journal Chemosphere, the researchers urge decision-makers to consider the combined impact of the mix of chemicals that accumulate in people and nature. “These […]

In a study published in Nature Communications, researchers at Karolinska Institutet provide insight into the sequence of events leading to the formation of functional mitoribosomes and sheds light on the mechanism of action of nine mitoribosome assembly factors involved in this process. The results may help yield novel opportunities for […]

Case Comprehensive Cancer Center, a partnership of Case Western Reserve University, University Hospitals and Cleveland Clinic, has joined with 71 other National Cancer Institute (NCI)-designated cancer centers and partner organizations to issue a joint statement urging the nation’s physicians, parents and young adults to get the human papillomavirus (HPV) vaccination back on […]

Researchers at the National Eye Institute (NEI) have determined how certain short protein fragments, called peptides, can protect neuronal cells found in the light-sensing retina layer at the back of the eye. The peptides might someday be used to treat degenerative retinal diseases, such as age-related macular degeneration (AMD). The […]

Medulloblastoma is a rare but devastating childhood brain cancer. This cancer can spread through the spinal fluid and be deposited elsewhere in the brain or spine. Radiation therapy to the whole brain and spine followed by an extra radiation dose to the back of the brain prevents this spread and […]

The intestinal disease necrotizing enterocolitis is a leading cause of death among premature infants born in the U.S. and across the globe. Characterized by excessive inflammation that can cause tissue decay in the bowels, the disease provides a pathway for infectious and deadly bacteria to enter the bloodstream. Despite four […]

The prevalence of genetic mutations associated with breast cancer in Black and white women is the same, according to a new JAMA Oncology study of nearly 30,000 patients led by researchers in the Basser Center for BRCA at the Abramson Cancer Center. About five percent of both Black and white women have a genetic mutation […]

Human babies do even more than we thought while sleeping. A new study from University of Iowa researchers provides further insights into the coordination that takes place between infants’ brains and bodies as they sleep. The Iowa researchers have for years studied infants’ twitching movements during REM sleep and how those twitches […]

A Rice University professor involved in the search for a way to treat and perhaps cure sickle cell disease is available to comment on a major advance revealed today in Science Translational Medicine. Rice University bioengineer Gang Bao is a pioneer in sickle cell research and a co-author of the breakthrough study released led […]

According to the Centers for Disease Control and Prevention, breast cancer ranks as the most prevalent cancer among American women. For over 40 years, mammography was the standard of care for breast cancer screening and detection but recently the popularity and use of digital breast tomosynthesis (DBT), or 3D mammography, […]

Adults who skip breakfast are likely to miss out on key nutrients that are most abundant in the foods that make up morning meals, a new study suggests. An analysis of data on more than 30,000 American adults showed that skipping breakfast – and missing out on the calcium in […]