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Researchers at UC San Francisco have observed a new feature of neural activity in the hippocampus – the brain’s memory hub – that may explain how this vital brain region combines a diverse range of inputs into multi-layered memories that can later be recalled. Using a special “micro-grid” recording device […]

Did you know that more than 90,000 Canadians are living with multiple sclerosis (MS)? That’s more than the number of people with HIV in the country. And yet it’s not widely talked about. Nathalie Arbour and Catherine Larochelle, researchers at the CHUM Research Centre (CRCHUM) and neurosciences professors at Université de Montréal, along […]

A gene called GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. The researchers, whose findings are published online in Developmental Cell, discovered that the protein encoded by GAS2 is crucial […]

Scientists at the National Institutes of Health determined that stomach inflammation is regulated differently in male and female mice after finding that androgens, or male sex hormones, play a critical role in preventing inflammation in the stomach. The finding suggests that physicians could consider treating male patients with stomach inflammation […]

Our body’s relationship with bacteria is complex. While infectious bacteria can cause illness, our gut is also teeming with “good” bacteria that aid nutrition and helps keep us healthy. But even the “good” can have bad effects if these bacteria end up in tissues and organs where they’re not supposed […]

What if you could predict which cells might become cancerous? Breast tissue changes dramatically throughout a woman’s life, so finding markers for sudden changes that can lead to cancer is especially difficult. Cold Spring Harbor Laboratory (CSHL) Associate Professor Camila dos Santos and her team identified and catalogued thousands of normal human and […]

The membrane pacemaker hypothesis suggests that the lipid composition of membranes, and particularly mitochondrial membranes, is an important determinant of species longevity in at least some clades, such as mammals and birds. Membrane composition determines the degree of resistance to lipid oxidation and consequent loss of function for component parts […]

There are billions of neurons in the human brain, and scientists want to know how they are connected. Cold Spring Harbor Laboratory (CSHL) Alle Davis and Maxine Harrison Professor of Neurosciences Anthony Zador, and colleagues Xiaoyin Chen and Yu-Chi Sun, published a new technique in Nature Neuroscience for figuring out connections using genetic tags. […]

Despite decades of research and investment, the genetic underpinnings of Alzheimer’s disease are still largely unknown, stymieing efforts at drug development and early diagnosis. To change that, a new grant will support the first comprehensive study to use whole-genome sequencing to address critical gaps in knowledge about the disease. The […]

By combining two medications, researchers at Michigan Medicine optimized therapy for people with gout, a condition that causes severe damage and disability if left untreated. The study revealed how a second drug taken orally more than doubled the effectiveness of Pegloticase, an intravenous gout treatment used to dissolve crystallized uric […]

Researchers here show that intermittent fasting alters the gut microbiome in ways that likely increase the production of butyrate. This metabolite is known to produce beneficial downstream effects, such as upregulation of BDNF and neurogenesis. As research into the gut microbiome in health and aging continues, an increased knowledge of […]

In 2015, researchers at UC San Francisco found a structure inside of tumor cells that biologists had never seen before. Even more surprising, a closer examination of the structure revealed that it contained signaling proteins known as receptor tyrosine kinases, or RTKs, which were thought to reside exclusively on the cell’s […]

Researchers at the University of Bristol have discovered how microbes responsible for human African sleeping sickness produce sex cells. In these single-celled parasites, known as trypanosomes, each reproductive cell splits off in turn from the parental germline cell, which is responsible for passing on genes. Conventional germline cells divide twice […]

Dental and orthopedic implants are widely used around the world. Common causes for implant failure are the immune response against oral bacteria and titanium particles shed by the implant. These and other phenomena can generate an inflammatory response, activating the osteoclasts (bone resorbing cells), and ultimately leading to osteolysis (destruction […]

University of Alberta scientists have identified a receptor in cells that could be key to preventing permanent hearing loss in childhood cancer survivors who are being treated with the drug cisplatin. The researchers believe by inhibiting the receptor, they may be able to eliminate toxic side-effects from the drug that […]

A new study with zebrafish shows that a deadly form of skin cancer — melanoma — alters the metabolism of healthy tissues elsewhere in the body. The research from Washington University in St. Louis suggests that these other tissues could potentially be targeted to help treat cancer. “Tumors rely on […]

The quest to create safer, more successful pregnancies is one of the top goals of modern science. While pregnancy is better understood today than ever before, with improvements in technology helping to lower the risk of negative outcomes, there is much researchers still don’t know about a vital part of […]

Over the last two years, Multiply Labs has helped pharmaceutical companies produce biologic drugs with its robotic manufacturing platform. The robots can work around the clock, precisely formulating small batches of drugs to help companies run clinical trials more quickly. Now Multiply Labs, which was founded by Fred Parietti PhD […]

Since it debuted in 2011, the Get SET Early program, which provides pediatricians and parents with a relatively simple process to screen for indicators of autism spectrum disorder (ASD) in children as young as age 1, has steadily grown in use and validation. Early screening and identification of ASD has […]

Researchers at the University of California San Diego have laid the groundwork for a potential new type of gene therapy using novel CRISPR-based techniques. Working in fruit flies and human cells, research led by UC San Diego Postdoctoral Scholar Zhiqian Li in Division of Biological Sciences Professor Ethan Bier’s laboratory […]

New research at Karolinska Institutet suggests a link between psychosis and a genetic change that affects the brain's immune system. The study published in Molecular Psychiatry may impact the development of modern medicines for bipolar disorder or schizophrenia. Psychosis affects approximately 2-3 per cent of the population and is characterized […]

Targeting a heat production ‘brake’ on fat tissues may be a safer way to treat obesity than current medication. A receptor that helps conserve energy when food is scarce may be the key to a safer approach to treating diet-induced obesity, research led by the Garvan Institute of Medical Research […]

Neglect, calamitous events or even abuse: traumatic childhood experiences increase the risk of mental and physical illness and can lead to psychiatric disorders later in life. But how do stressful events early in life persistently affect brain functions? What happens in a child’s nerve cells when fear and stress overwhelm […]

Sleep is very important for us and you know it. If you don’t get a good night’s sleep, you definitely feel it. Duration of sleep is important, but other factors play a huge role as well. For example, interruptions. A new study from the University of Adelaide has revealed that […]

Is there any hope for people who are suffering from incurable diseases? Modern medicine shed light in the darkness in the form of a novel therapy, gene therapy. Gene therapy is a relatively new experimental technique, which uses the gene to treat, prevent or limit illness development. It is based […]

Simultaneous measurement of neural rhythms and spikes across five brain areas reveals how propofol induces unconsciousness. In a uniquely deep and detailed look at how the commonly used anesthetic propofol causes unconsciousness, a collaboration of labs at the Picower Institute for Learning and Memory at MIT shows that as the […]

Ask Paul Guenard how he’s doing and he’ll tell you, “Not bad for a guy who’s supposed to be dead!” While he laughs as he says it, Guenard did indeed face death six years ago when he underwent a stem cell transplant to treat mantle cell lymphoma. Afterwards, he said, […]

Investigational gene therapy can safely restore the immune systems of infants and children who have a rare, life-threatening inherited immunodeficiency disorder, according to research supported in part by the National Institutes of Health. The researchers found that 48 of 50 children who received the gene therapy retained their replenished immune […]

Americans are in chronic pain, and a comprehensive new study exploring trends in this major public health concern reveals that what has been a long-standing and under-acknowledged problem is getting substantially worse. The findings, published in the latest issue of the journal Demography, suggest blanket increases across multiple measures, with pain rising […]

Scientists at UC San Francisco are learning how immune cells naturally clear the body of defunct – or senescent – cells that contribute to aging and many chronic diseases. Understanding this process may open new ways of treating age-related chronic diseases with immunotherapy. In a healthy state, these immune cells […]