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Although prostate cancer is one the most common types of malignancy in men, diagnosis is typically made on the basis of the Prostate-specific antigen (PSA), with an accuracy as low as 30%. Given how unreliable PSA-based testing can often be, many patients require invasive biopsy which often leaves them with […]

A fundamental process by which cellular components are degraded is Autophagy. Defects in Autophagy pathways are strongly associated with multiple human diseases, including neurodegenerative disorders and cancer. Despite their importance, to date, a comprehensive characterization of the extent and selectivity for Autophagic degrades has remained largely uncharacterized. Researchers at Karolinska […]

Liverpool cancer researchers have contributed to important new findings of the positive role of androgens in breast cancer treatment, with immediate implications for women with oestrogen receptor-positive (ER-positive) advanced disease. ER-positive breast cancer is the most common type of breast cancer diagnosed today, accounting for around 75 out of every […]

One more piece of the puzzle has fallen into place behind a new drug whose anti-cancer potential was developed at the University of Alberta and is set to begin human trials this year, thanks to newly published research. “The results provide more justification and rationale for starting the clinical trial in […]

NineSigma, representing Suntory Global Innovation Center Ltd. (“Client”), which serves as the Suntory Group's basic research department, seeks technologies for making a minimally invasive assessment of cellular senescence in the human clinical setting. The Client has in mind biomarker-based assessment methods but welcomes proposals for a wide range of other approaches. Anti-ageing is […]

Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease. Published in Nature Medicine, the international study conducted in collaboration with the Garvan Institute of Medical Research, looked at the […]

There is currently no cure for osteoarthritis, but a group of scientists believe they’ve discovered a method through which a simple knee injection could potentially stop the disease’s effects. These researchers showed that they could target a specific protein pathway in mice, put it into overdrive and halt cartilage degeneration […]

The abnormal immune system response that causes multiple sclerosis (MS) by attacking and damaging the central nervous system can be triggered by the lack of a specific fatty acid in fat tissue, according to a new Yale study. The finding suggests that dietary change might help treat some people with […]

Fisetin is perhaps the most intriguing of the first generation senolytic compounds, those capable of selectively destroying senescent cells in old tissues and thus producing rejuvenation to a meaningful degree. Senolytics have been demonstrated in animal studies to reverse many age-related conditions to a greater degree than any other approaches. […]

Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own. There are two […]

A scientific study carried out by the Universidad Carlos III de Madrid (UC3M) and the Universidad Complutense de Madrid (UCM) has produced a mathematical description of the way in which a tumour invades the epithelial cells and automatically quantifies the progression of the tumour and the remaining cell islands after […]

Human genes have an impact on shaping our gut ecosystem according to new evidence from the international MIBioGen consortium study involving more than 18,000 people. The findings, led by the University Medical Center Groningen, Netherlands and involving researchers at the University of Bristol, are published today [18 January] in Nature […]

As the number of people who have fought off SARS-CoV-2 climbs ever higher, a critical question has grown in importance: How long will their immunity to the novel coronavirus last? A new Rockefeller study offers an encouraging answer, suggesting that those who recover from COVID-19 are protected against the virus […]

Targeted neuromodulation tailored to individual patients’ distinctive symptoms is an increasingly common way of correcting misfiring brain circuits in people with epilepsy or Parkinson’s disease. Now, scientists at UC San Francisco’s Dolby Family Center for Mood Disorders and Weill Institute for Neurosciences have demonstrated a novel personalized neuromodulation approach that – at least in […]

Anyone who has tried and failed to meditate knows that our minds are rarely still. But where do they roam? New research led by UC Berkeley has come up with a way to track the flow of our internal thought processes and signal whether our minds are focused, fixated or […]

Today's open access research paper is a reminder of one of the more direct mechanistic links between vascular aging and brain aging. Blood vessels stiffen with age, becoming progressively worse at the necessary task of contracting and relaxing in response to circumstances. This is in part due to cross-linking in […]

In addition to a skin rash, many eczema sufferers also experience chronic itching, but sometimes that itching can become torturous. Worse, antihistamines — the standard treatment for itching and allergy — often don’t help. New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often […]

Waldenström macroglobulinemia (WM), a rare form of lymphoma, does not have any known cure and only one FDA-approved treatment making it challenging to treat patients. Researchers at the University of New Hampshire took the novel approach of targeting specific cell proteins that control DNA information using inhibitors, or drugs, that […]

There is far too much incrementalism in the present research and development of therapies to treat aging. Much of the field is engaged in mimicking calorie restriction or repurposing existing drugs that were found to increase mouse life span by a few percentage points. This will not meaningfully change the […]

In the 1920s, German chemist Otto Warburg discovered that cancer cells don’t metabolize sugar the same way that healthy cells usually do. Since then, scientists have tried to figure out why cancer cells use this alternative pathway, which is much less efficient. MIT biologists have now found a possible answer […]

Researchers at the Center for Computational Imaging and Personalized Diagnostics (CCIPD) at Case Western Reserve University have preliminarily validated an artificial intelligence (AI) tool to predict how likely the disease is to recur following surgical treatment for prostate cancer. The tool, called RadClip, uses AI algorithms to examine a variety of data, […]

Haruhiko Morita had never aspired to be an entrepreneur, but his astute foresight was instrumental in landing his current position of a chief executive officer at Modalis Therapeutics Corp. In the late 1980s and early 1990s, while Morita was an undergraduate and graduate student at the Faculty of Engineering and […]

Frailty is usually accompanied by greater immune dysfunction, given that chronic inflammation is a strong component of both immune aging and the various dysfunctions of frailty. Thus frail individuals exhibit a worse response to vaccinations intended to prevent infectious disease. This is unfortunate, as this is the population in greatest […]

Chronic back pain can keep us from living our best lives, but a University of Alberta study shows why some people don’t let it stop them. The research, published in the Journal of Occupational Rehabilitation, sheds light on what motivates people to soldier through their persistent pain. The qualitative study is one […]

New tool reveals details about motor neuron circuitry in fruit flies. How do networks of neurons connect to form functional circuits? To address this long-standing question in neuroscience, researchers from Boston Children's Hospital and Harvard Medical School have developed a new pipeline to study neural circuits and, in the process, […]

Dopamine is one of the essential neurotransmitters in the brain. Its action is limited to the brain; it acts as a chemical messenger throughout the body. Dopamine stimulates the cardiovascular system's work and is responsible for cognitive abilities, coordination of movements, and even feelings. Here, we will try to explain […]

Cancer is a notoriously complex disease, in part because it may be caused by mutations among hundreds or even thousands of genes. In addition, most cancers exhibit an extraordinary amount of variation among genetic mutations, even between patients with the same types of cancers. Consequently, cancer researchers have chosen to […]

pandemics and epidemics, public health officials must identify individuals who are actively infected or have previously been infected, both to control the spread of disease and, in the case of vaccine-preventable illnesses, to prioritize individuals for vaccination. The SARS-CoV-2 pandemic has shone a bright light on the crucial need for […]

Researchers have developed a blood test that could make it possible for doctors to detect — then quickly prevent or slow down — acute heart transplant rejection, a potentially deadly condition that occurs in the early months after a patient has received a donor heart. They estimate that the test […]

For many years, researchers at the National Food Institute, Technical University of Denmark have studied the harmful effects of chemicals and developed methods to best and most effectively investigate their harmful effects. Of the many thousands of chemical substances to which humans can be exposed, the majority has not been […]