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A woman who defied a genetic mutation that guarantees early-onset Alzheimer’s donates her brain to research. Her life was nothing short of a miracle. Born into an extended family of 6,000, all of whom share a rare genetic mutation that inescapably leads to Alzheimer’s disease (AD) by the age of […]

One of the key difficulties in the treatment of cancer is the fact of its evolution being parallel to our own. This makes developing effective drugs a complex and on-going process. Another challenge faced by researchers is the effective delivery of drugs directly to malignant cells without damaging healthy organs […]

White blood cells are part of many immune system responses in the human body. New research shows that a specific type of those cells may cause brain cancer tissues to die — but that’s not good news, according to researchers at Penn State College of Medicine. They said that higher amounts […]

In cell-based immunotherapy, a treatment being explored for cancer, the body’s immune cells are modified to eliminate cancer cells more effectively. Immune cells can kill cancer cells on their own but have some difficulty recognizing the substance produced by tumors that provides information on what cells to target. Researchers at […]

The absence of a protein that works to prevent tumor formation may explain why some patients are resistant to a common cancer therapy, according to Penn State College of Medicine researchers. They said that testing cancers for the presence of this protein may help clinicians identify patients who may be resistant to […]

Fibrous proteins such as collagen and fibrinogen form a thin solid layer on the surface of an aqueous solution similar to the “skin” that forms on warm milk, according to a team of Penn State Researchers, who believe this finding could lead to more efficient bioprinting and tissue engineering. In […]

Scientists have tracked the very early stages of human foetal gut development in incredible detail, and found specific cell functions that appear to be reactivated in the gut of children with Crohn’s Disease. The results are an important step towards better management and treatment of this devastating condition. The research from the University of […]

Injecting a gene therapy vector into one eye of someone suffering from LHON, the most common cause of mitochondrial blindness, significantly improves vision in both eyes, scientists have found. In a landmark phase 3 clinical trial, the international team, coordinated by Dr Patrick Yu-Wai-Man from the University of Cambridge and Dr José-Alain […]

Researchers have identified the driving force behind a cellular process linked to neurodegenerative disorders such as Parkinson’s and motor neurone disease. In a study published in Science Advances, researchers from the University of Cambridge show that tiny components within the cell are the biological engines behind effective protein production. The endoplasmic […]

Calcification of blood vessel walls progresses with age, an issue that sees cells behave as through they are in bone tissue, a maladaptive reaction to the altered signaling environment and damage of aged tissue. The resulting deposition of calcium makes normally flexible cardiovascular tissue stiff and dysfunctional, ultimately contributing to […]

Sophia Ceder and Klas Wiman and their colleagues at Department of Oncology-Pathology have together with researchers from Peter MacCallum Cancer Center, University of Melbourne, University of Cambridge and Aprea Therapeutics published a study in EMBO Molecular Medicine that provides novel understanding on the mechanisms of mutant p53 targeting compound APR-246. […]

For the first time, scientists at the University of Zurich have been able to observe stem cells in the adult mouse brain that divide over the course of several months to create new nerve cells. The study shows that brain stem cells are active over a long period, and thus […]

Here, researchers explore the mechanisms governing changes in cell behavior during reprogramming. Many of the aspects of aging found in cells taken from old tissues can be reversed via the process of reprogramming these cells into induced pluripotent stem cells. Mitochondrial function is restored to youthful levels, for example, as […]

University of Minnesota Twin Cities researchers in the Department of Chemistry have created a new polymer to deliver DNA and RNA-based therapies for diseases. For the first time in the industry, the researchers were able to see exactly how polymers interact with human cells when delivering medicines into the body. […]

Daniela Latorre wanted to be a scientist since she was a child. At the Institute for Research in Biomedicine, affiliated to the USI in Bellinzona and the Institute of Microbiology, she is finding evidence that narcolepsy is an autoimmune disease. She has now received the Pfizer Prize for Research 2020 […]

A new study, led by researchers at the University of Bristol and the International Agency for Research on Cancer (IARC), has revealed that where fat is on our body may lead to different health outcomes for men and women. The research, co-funded by World Cancer Research Fund (WCRF), Cancer Research […]

Individuals with high ADHD-traits that do not meet the criteria for a diagnosis are less able to perform tasks involving attentional regulation or emotional control after a sleepless night than individuals with low ADHD-traits, a new study from Karolinska Institutet published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging reports. While […]

The first study to compare molecular landscapes of early-onset and late-onset appendiceal cancer has revealed distinct non-silent mutations in the tumors of younger patients, setting the stage for the development of potential therapeutic advances for this rare disease. The findings, published in JAMA Network Open, were derived from an analysis […]

Scientists have revealed a mechanism that causes heart cells to age and identified a drug that can rejuvenate them, according to a study published in eLife.  The drug is now in clinical trials. The results provide the first direct evidence that aging increases proton leakage in heart cells. The findings […]

Senescent cell accumulation is an important cause of degenerative aging. Senescent cells cease replication and begin to secrete an inflammatory mix of signals that disrupt tissue structure and function. These cells are created constantly, largely as a result of somatic cells hitting the Hayflick limit on cellular replication, but also […]

A combination approach to treating a prevalent glioma subtype — including metabolic reprogramming, radiation, chemotherapy and immunotherapy — led to a complete regression of tumors in 60% of study mice, new research by the University of Michigan Rogel Cancer Center found. The findings, which appear in the Journal of Clinical Investigation, support the testing […]

Systemic sclerosis is an autoimmune disease associated with inflammation and fibrosis, or scarring, that affects organs including the skin, heart, kidney and lungs. This form of scleroderma, this tightening and thickening of the skin, is a progressive, orphan illness that affects approximately 80,000 Americans and has no clear pathogenesis or FDA […]

Chronic inflammation grows with age throughout the body, characterized by increased levels of numerous inflammatory signal molecules, among which is IL-6. One contributing factor to the chronic inflammation of aging is the accumulation of lingering senescent cells, which rouse the immune system via secreted molecules that include, prominently, IL-6. Researchers […]

Children who undergo cataract surgery as infants have a 22% risk of glaucoma 10 years later, whether or not they receive an intraocular lens implant. The findings come from the National Eye Institute (NEI)-funded Infant Aphakic Treatment Study, which today published 10-year follow-up results in JAMA Ophthalmology. NEI is part […]

Fractured sleep, daytime sleepiness and other signs of disturbance in one’s circadian rhythm are common complaints of people with Alzheimer’s disease, and the problems only get worse as the disease progresses. But the reason for the link between Alzheimer’s and circadian dysfunction is not well understood. Researchers at Washington University […]

Ribosomes are the machines in the cell that use instructions from mRNA to synthesize functional proteins. There are hundreds of thousands of ribosomes in each cell, and they mostly process their instructions faithfully. But sometimes ribosomes get stuck or stall on roadblocks along with defective mRNA molecules. New research from […]

Researchers here note a study population in which glucosamine use correlates with a reduction in mortality risk that is of a similar size to that associated with exercise. One always has the suspicion that, even after controlling for such things, the use of less common supplements is just a marker […]

University of Alberta researchers are among two Canadian research teams chosen for significant new funding from the Government of Canada and JDRF Canada to develop new stem cell-based therapies for treating Type 1 diabetes. The projects will each receive $1.5 million from the Canadian Institutes of Health Research Institute of Nutrition, Metabolism […]

Female COVID-19 patients face less severe disease complications and a lower risk of dying than male patients thanks to hormones and chromosomes that contribute to a stronger immune response, according to new research from a University of Alberta-led team. “The highlight of our study is how the sex differences in COVID-19 are […]

More and more evidence is coming out that people with COVID-19 are suffering from cognitive effects, such as brain fog and fatigue. And researchers are discovering why. The SARS-CoV-2 virus, like many viruses before it, is bad news for the brain. In a study published in Nature Neuroscience, researchers found […]