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Immunotherapies are a promising anticancer arsenal and work by mobilizing the immune system to recognize and destroy cancer cells. Currently, however, only a third of patients respond to immunotherapies, in part because the tumour environment can be hostile to immune cells, depriving them of their source of energy, which diminishes treatment […]

A consensus more than 90-years-old on the mechanisms which regulate the day-night rhythm in heart rate has been fundamentally challenged by an international team of scientists from Manchester, London, Milan, Maastricht, Trondheim and Montpellier. The vagus nerve – one of the nerves of the autonomic nervous system which supplies internal […]

An international study has found a link between the brain’s network connections and grey matter atrophy caused by certain types of epilepsy, a major step forward in our understanding of the disease. In neuroscience, it is becoming increasingly clear that the brain’s connectome is as important as its anatomy when […]

Scientists reverse age-related vision loss, glaucoma damage in mice. Harvard Medical School scientists have successfully restored vision in mice by turning back the clock on aged eye cells in the retina to recapture youthful gene function. The team’s work, described in Nature, represents the first demonstration that it may be possible […]

The labyrinth of jumbled blood vessels in the tumour microenvironment remains one of the toughest blockades for cellular therapies to penetrate and treat solid tumours. Now, in a new study published online in Nature Cancer, Penn Medicine researchers found that combining chimeric antigen receptor (CAR) T cell therapy with a PAK4 […]

Rusted iron pipes can react with residual disinfectants in drinking water distribution systems to produce carcinogenic hexavalent chromium in drinking water, reports a study by engineers at UC Riverside. Chromium is a metal that occurs naturally in the soil and groundwater. Trace amounts of trivalent chromium eventually appear in the drinking […]

When healthcare professionals treat patients suffering from advanced cancers, they usually need to use a combination of different therapies. In addition to cancer surgery, the patients are often treated with radiation therapy, medication, or both. Medication can be combined, with different drugs acting on different cancer cells. Combinatorial drug therapies […]

A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein, a hallmark of Alzheimer’s disease and several other neurodegenerative disorders. Their findings may help to better understand the […]

If stem cell science were bread baking, then working with pluripotent stem cells would be like starting with flour, water and yeast. Transforming those base materials into a delicious loaf of bread requires knowing which ingredients to add and how to manipulate the dough and its environment, such as by mixing […]

In mouse study, loss of molecule contributes to disease while surplus reduces symptoms. Osteoarthritis is one of the most common problems associated with ageing, and although there are therapies to treat the pain that results from the breakdown of the cartilage that cushions joints, there are no available therapies to […]

Millions of sperm enter the race to fertilize, but only one wins the sprint to the egg. Now Yale researchers have discovered that these winning sperm possess a few key molecular characteristics that differentiate them from those left behind, they report in the journal eLife. Sperm tails are lined with […]

A team co-led by a scientist at the University of California, Riverside, has developed a method to study how HIV mutates to escape the immune system in multiple individuals, which could inform HIV vaccine design. HIV, which can lead to AIDS, evolves rapidly and attacks the body’s immune system. Genetic mutations in […]

University of Minnesota researchers have discovered a potential target for the research and development of future therapies to mitigate the symptoms of a series of genetic disorders called laminopathies. Laminopathies cause a wide variety of conditions in humans, from skeletal muscular dystrophy and neuropathy to premature ageing. In a study […]

Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study by UC San Francisco scientists. The drug, called ISRIB, has already been shown in laboratory studies to restore memory function months after traumatic brain injury (TBI), reverse […]

Healthy cells and cells with Type 2 diabetes use completely different pathways to manage blood sugar levels, according to results from a study in mice. Researchers used a trans-omic approach, combining data from genes (transcriptomics) and metabolites (metabolomics) to identify and connect the many separate processes involved in responding to […]

Neuroscientists don’t know precisely what brain circuits control wakefulness and sleep, nor exactly how drugs for general anaesthesia affect those circuits. But a new study from Penn Medicine researchers brings neuroscience a step closer to solving that important conundrum. A team of researchers from the Perelman School of Medicine at […]

As time goes by, the tips of your chromosomes—called telomeres—become shorter. This process has long been viewed as an unwanted side-effect of ageing, but a recent study shows it is in fact good for you. “Telomeres protect the genetic material,” says Titia de Lange, Leon Hess Professor at Rockefeller. “The DNA […]

About 25 per cent of the U.S. population suffers from fatty liver disease, a condition that can lead to fibrosis of the liver and, eventually, liver failure. Currently, there is no easy way to diagnose either fatty liver disease or liver fibrosis. However, MIT engineers have now developed a diagnostic […]

While doctors can successfully treat some types of skin cancer at the surface with human-engineered viruses, scientists have yet to find a way to inject these types of viruses to seek and destroy other cancers in the body, such as lung cancer. But medical researchers at Case Western Reserve University […]

A new study led by researchers at UC San Francisco has found that among older Americans with cognitive impairment, the greater the air pollution in their neighbourhood, the higher the likelihood of amyloid plaques – a hallmark of Alzheimer’s disease. The study adds to a body of evidence indicating that […]

New research has discovered a cell type that governs the way bones form and maintains themselves, opening up a potential target for future therapies for bone disorders like osteoporosis. Led by faculty from the Perelman School of Medicine at the University of Pennsylvania, a rodent study showed that bone marrow […]

Our gut microbiomes — the many bacteria, viruses and other microbes living in our digestive tracts — play important roles in our health and risk for disease in ways that are only beginning to be recognized. University of California San Diego researchers and collaborators recently demonstrated in older men that […]

The brains of healthy adults recovered faster from a mild vascular challenge and performed better on complex tests if the participants consumed cocoa flavanols beforehand, researchers reported in the journal Scientific Reports. In the study, 14 of 18 participants saw these improvements after ingesting the flavanols. Previous studies have shown […]

Gut hormones play an important role in regulating fat production in the body. One key hormone, released a few hours after eating, turns off fat production by regulating gene expression in the liver, but this regulation is abnormal in obesity, researchers at the University of Illinois Urbana-Champaign found in a […]

A proof-of-concept study conducted in a mouse model of Alzheimer’s disease offers new evidence that copper isotopes can be used to detect the amyloid-beta protein deposits that form in the brains of people living with – or at risk of developing – Alzheimer’s. Several types of isotopes give off positively […]

When the heart develops, some of its coronary blood vessels develop from cells lining the inner surface of the heart’s ventricular chambers (endocardium). Novel findings suggest that new blood vessel growth in the heart can be stimulated with the VEGF-B growth factor from the same source after myocardial infarction to […]

Michael Antonov is one of a number of high net worth individuals who are interested in accelerating progress towards a first generation of comprehensive rejuvenation therapies, targeting all of the mechanisms of aging in order to cure age-related disease and extend healthy life spans. The SENS Research Foundation remains one […]

Every cell contains a herd of hundreds of mitochondria, organelles descended from ancient symbiotic bacteria. The primary purpose of mitochondria is to package the chemical energy store molecule adenosine triphosphate (ATP) that is needed to power cellular processes. Each mitochondrion contains one more copies of a small circular genome, the […]

A world-leading £1.5 million research programme that aims to achieve scar-free healing within a generation has been launched by The Scar Free Foundation, the only medical research charity which focuses solely on scarring. The five-year research study led by the University of Bristol will identify the gene(s) that causes scarring […]

Shihua Sun has investigated the associations between attention-deficit/hyperactivity disorder (ADHD) and specific adverse outcomes including asthma and premature death. In his thesis, Shihua included four studies to clarify the magnitude and aetiology of the associations, as well as potential effects from medication treatment that may prevent poor prognosis. ADHD is […]