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Deleting the TSC2 gene in specific lung cells of mice led to the activation of the mTORC1 signalling pathway and pulmonary disease characteristics consistent with human LAM disease, particularly in female breeder mice. These mice without TSC2 also exhibited a dysfunctional WNT cellular signalling pathway, which is also tied to lung […]

IMDEA Nanociencia researchers present a new family of organometallic iridium complexes that generate cytotoxicity only upon intracellular activation. Chemotherapy is defined as the use of chemicals to reach and damage cancer cells. On its way towards the tumour, the drugs can affect healthy cells as well. For example, cisplatin, a […]

Study debunks common myth that hormonal contraceptives cause depression, suicide in women. Women who struggle with mental illness often don’t take the most effective birth control methods because they worry the hormones in these contraceptives can trigger depression and suicide, a myth that has been perpetuated by recent studies. A […]

As researchers and medical professionals work to develop new treatments for cancer, they face a variety of challenges. One is intratumor heterogeneity — the presence of multiple kinds of cancer cells within the same tumor. Often, these “mosaic” tumors include cells, such as polyploidal giant cancer cells, that have evolved […]

A tiny fish is helping scientists understand how the human brain processes sound, while also giving insight to autism spectrum disorder. Scientists at The University of Queensland used zebrafish that carry the same genetic mutations as humans with Fragile X syndrome and autism, and discovered the neural networks and pathways that produce […]

Researchers at Karolinska Institutet have investigated the association between certain immune markers in neonates and the risk of later developing autism spectrum disorder (ASD). They found that mid-levels of a classical marker of inflammation, C-reactive protein, were associated with the lowest risk for ASD – whereas too much or not […]

Radiation and chemotherapy are designed to kill cancer cells. But for many patients, cancer cells can survive even after being hit with high doses of chemotherapy or radiation. To make treatment more effective, scientists are focusing on ways to tweak the inner machinery of cancer cells to make them more […]

A new UC Riverside study shows flame retardants found in nearly every American home cause mice to give birth to offspring that become diabetic. These flame retardants, called PBDEs, have been associated with diabetes in adult humans. This study demonstrates that PBDEs cause diabetes in mice only exposed to the […]

A novel computational method that quantifies for the first time the coordination level between different genes reveals a new hallmark of aging which could require a change of course in current efforts to develop healthy-aging treatments. Although all humans share similar changes during aging such as gray hair, wrinkles, and […]

Cancer affects millions and millions of people every year. Scientists would like to encourage our own immune system to attack it, which is why immunotherapies are probably the most promising treatments for cancer. Now scientists at UCL developed a new kind of immunotherapy, which launches a two-pronged attack against melanoma, […]

Dementia is in the cards for many. It is a common typically age-related cognitive decline, which is a burden for the patients and their families. Dementia is an incurable condition and one of the most common causes of death as well. It is estimated that around 50 million people globally […]

BioVaxys Technology Corp. (CSE: BIOV) (“BioVaxys” or “the Company”), a world leader in haptenized protein vaccine research and development, announced that it has filed a Provisional Patent Application with the U.S. Patent and Trademark Office entitled “Method and kit for detection of cell mediated immune response” related to the potential […]

Nerve injury is a common clinical problem. The repair or regeneration of the defective nerve is a complex process. Peripheral nerves have a limited capacity to regenerate after an injury. Microvesicles are a type of extracellular vesicles that are released from the cell membrane. The membranes of mesenchymal stem cells, […]

A team of researchers led by a University of Alberta pharmacology professor has mapped the function and gene expression of individual insulin-producing cells within the human pancreas, opening new paths of research for diagnosing and treating diabetes. “There’s been a lot of excitement the last few years about understanding how pancreatic beta […]

Research by University at Buffalo biomedical engineers Ruogang Zhao and Yun Wu may help discover new drugs to treat pulmonary fibrosis, a severe lung disease that can be life-threatening. Pulmonary fibrosis has many causes, including smoking, ageing, environmental factors and viral infections, such as those associated with COVID-19. There is […]

A team of University at Buffalo researchers have published a paper in Nature Communications that is helping to define the best time to give specific treatment to infants born with Krabbe disease (KD). This treatment has been found to prolong life for these infants, for as long as a few […]

Calcitonin, a well-known thyroid hormone that helps regulate bone mass and collagen production, is also produced by cells in the heart, researchers in Canada, the U.S., the U.K. and Australia have found. Published in Nature, their breakthrough promises to aid in developing new treatments for people with atrial fibrillation (AF), a common […]

Small shifts in ocean temperature can have significant effects on the eating habits of blackfin tuna during the larval stage of development when finding food and growing quickly are critical to long-term survival, a new study from Oregon State University researchers has found. In a year of warmer water conditions, larval […]

The standard approach of assessing long-term risk for atherosclerotic cardiovascular disease (ASCVD) works just as well for patients who are overweight as they do for patients at an optimal weight, according to a new study in JAMA Network Open. Led by Rohan Khera, MD, MS, an assistant professor of cardiovascular medicine at […]

A new study has shown pregnant women with obesity could reduce the health risks for their infants through improved diet and more physical activity. Research published in the journal PLosMed investigates the impact of high glucose in mothers with gestational diabetes mellitus (GDM) and changes to infants DNA. GDM is […]

A new study suggests that it is possible to design drugs that can target a type of shape-shifting protein involved in Alzheimer’s disease, which was previously thought to be undruggable. A team of researchers, led by the University of Cambridge, have identified a new mechanism of targeting amyloid-beta, a protein […]

Scientists have used gene therapy to regenerate damaged nerve fibres in the eye, in a discovery that could aid the development of new treatments for glaucoma, one of the leading causes of blindness worldwide. Axons – nerve fibres – in the adult central nervous system (CNS) do not normally regenerate […]

Cornell researchers have identified three genes responsible for changing the color of common buckeye butterfly wings, depending on what time of year the egg hatches and larvae develop. If the larvae develop early in the year, when days are shorter and colder, the butterflies (Junonia coenia) reach maturity in summer with […]

A new Liverpool led study, published in Diabetologia, presents the results of the largest clinical trial for diabetic retinopathy. The study highlights a new approach that could transform diabetic eye screening around the world that also has a significant cost saving for the NHS. The number of people living with diabetes […]

It's the holy grail of synthetic biologists: creating a living cell from scratch. So far they’ve managed to make simple prototypes—essentially tiny fat balloons with a soup of genetic material inside, capable of reading genetic code, producing proteins, and transporting molecules around. Yet these artificial blobs lack an essential feature […]

Night-shift workers face an increased risk of obesity and diabetes, but the underlying reason for that has been a mystery. Now, University of Missouri School of Medicine researchers have found a potential cause for metabolic changes during night-shift work that creates confusion between cells in the body and the central clock in […]

The body's immune system defeats diseases by sensing foreign invaders, such as bacteria or viruses, then mounting a response against them. But how immune cell receptors work together to sense multiple molecules and make these decisions remained a mystery. Now, researchers at the Pritzker School of Molecular Engineering at the University […]

Researchers at the University of Michigan Rogel Cancer Center have identified a promising targeted therapy against the basal subtype of bladder cancer by screening 3-D cell cultures. MEK inhibitors showed the strongest response against the basal molecular subtype, the research group reported in Oncotarget. “It’s becoming more and more clear that […]

Gut-trained immune cells at CNS borders guard against meningitis and other infections. The membranes surrounding our brains are in a never-ending battle against deadly infections, as germs constantly try to elude watchful immune cells and sneak past a special protective barrier called the meninges. In a study involving mice and […]

Unrelated mutations, when present in the blood, can lead to false positive results in men with advanced prostate cancer who are undergoing liquid biopsies.  Such tests, which look for variants in the cell-free DNA that tumors shed into the blood plasma, help determine suitable treatment options. “You can actually measure […]