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A new multi-institution, dose-determining clinical trial of a compound against metastatic, castration-resistant prostate cancer showed promising results, researchers reported in Clinical Cancer Research. The phase 1b/2a study of the pan-BET bromodomain inhibitor ZEN-3694 in combination with enzalutamide was led by researchers at the University of Michigan Rogel Cancer Center, the University of California, San Francisco, […]

Enzalutamide is one of the main treatments for patients with metastatic, castration-resistant prostate cancer — the lethal form of the disease. However, treatment options are limited for those who develop resistance to enzalutamide. Now, a multi-institution team has uncovered new clues that may help overcome resistance in some patients, according […]

The Encyclopedia of DNA Elements (ENCODE) Project(link is external) is a worldwide effort to understand how the human genome functions. With the completion of its latest phase, the ENCODE Project has added millions of candidate DNA “switches” from the human and mouse genomes that appear to regulate when and where genes are […]

Two decades or more before symptoms arise, plaques of a sticky protein called amyloid to begin forming in the brains of people later diagnosed with Alzheimer’s disease. Researchers at Washington University School of Medicine in St. Louis have shown that levels of a specific protein in the blood rise as […]

Florida State University Professor of Biological Science David Gilbert is using the latest information about the human genome as a guide to better understand cancer. Gilbert and his FSU colleagues were part of a team that compared different cancer cell types to a database of normal human cells using a […]

The molecular chaperone protein known as heat shock protein 90 (Hsp90) helps stabilize a number of proteins that are involved in tumor growth. This is why inhibitors that act on the protein have been investigated as potential anti-cancer drugs. So far, however, the inhibitors developed by various academic groups and […]

When we get a wound on our skin, the cells in our bodies quickly mobilize to repair it. While it has been known how cells heal wounds and how scars form, a team led by researchers from Washington University in St. Louis has determined for the first time how the […]

Many children treated for childhood malnutrition in developing countries never fully recover. They suffer from stunted growth, immune system dysfunction and poor cognitive development that typically cause long-term health issues into adulthood. Now, new research from Washington University School of Medicine in St. Louis and the International Centre for Diarrhoeal […]

Alone genetic mutation can cause a life-changing disorder with effects on multiple body systems. Lysosomal storage diseases, for example, of which there are dozens, arise due to single mutations that affect the production of critical enzymes required to metabolize large molecules in cells. These disorders affect multiple organs including, notably, […]

A new comparison of two breast-screening technologies has found that, for most women, digital breast tomosynthesis (DBT, also called 3D mammography) is superior to digital mammography for cancer detection and for reducing recall visits due to unclear or false findings. The study’s distinction, though, is in identifying women for whom […]

New findings by chemists Wolfgang Peti and Rebecca Page provide a foundation to better understand and treat these neurological disorders. From the movement of a finger to the creation of a memory, actions of the human body require the harmonious concert of protein interactions. A system of checks and balances […]

https://www.sciencedirect.com/science/article/pii/S2213671120302411A team of British and American scientists have discovered a way to slow the growth of breast cancer stem cells in the lab. The study led by Dr Bruno Simões and Professor Rob Clarke from The University of Manchester could eventually lead to combination drug therapies on previously untreatable breast […]

Biologists have known for some time that RNA interference can silence genes in far-​off cells. They suspected that a messenger substance “transmits” RNA interference. Now, ETH researchers have definitively shown that these messengers in plants are short double-stranded RNA fragments. In most organisms, small bits of RNA play a key […]

Cancer researchers Alex Huang, Reshmi Parameswaran, and Yamilet Huerta have been awarded $315,000 in grants from the St. Baldrick’s Foundation to conduct research of new immunotherapy treatments for pediatric cancers. Huang, professor of pediatrics at Case Western Reserve University School of Medicine and co-leader of the Hematopoietic and Immune Cancer […]

New technologies accelerate high-resolution imaging of human chromosomes in single cells. The intricate, tightly wound structures of chromosomes condense about two meters of DNA so the complete instruction manual for growing a human can be tucked inside a cell nucleus just 10 microns wide. “This is like fitting something the […]

A new study, which analyzed 40 years of Framingham Heart Study data, found an association between lowered rates of hip fractures and decreases in smoking and heavy drinking. The rates of hip fractures in the United States have been declining over the past few decades. Although some experts attribute this […]

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, Penn Medicine researchers show in a new study published online in Science. Human bodies contain over 200 different types of specialized cells. […]

Yale School of Medicine and the biopharmaceutical firm AI Therapeutics have launched a multi-institutional clinical trial of a drug for treating COVID-19. Known as LAM-002A (apilimod), the drug has a proven safety record. Preliminary research has shown it can block cellular entry and trafficking of the SARS-CoV-2 virus, the cause […]

Human pregnancy can easily be taken for granted as a natural and regularly occurring event, but it is the product of the complex, coordinated function of two bodies, mother and baby, that has evolved side by side with other important human adaptations. For the first time, researchers have established how […]

The number of people in the U.S. living with Alzheimer’s or dementia is expected to triple by 2050, and the latest research from the Alzheimer’s Association shows that half of the medical providers are not prepared to care for them. Now, new recommendations from a National Institutes of Health working group on […]

When our neurons — the principal cells of the brain — die, so do we. Most neurons are created during embryonic development and have no “backup” after birth. Researchers have generally believed that their survival is determined nearly extrinsically, or by outside forces, such as the tissues and cells that neurons supply with […]

New method to improve the diagnosis of genetic diseases. Breaks and rearrangements in the genome can lead to severe diseases, even if all genes remain intact. Hi-C, a method to map the three-dimensional structure of chromosomes, promises more reliable and accurate diagnoses of such defects, but is not used in […]

Research from The University of Western Australia has found a diet rich in nutrients and antioxidants may prevent or even reverse the effects of Alzheimer’s disease. The study, published in Open Biology, found taking a combination of antioxidants at increasing doses was more beneficial at preventing the debilitating disease than any other […]

Early menstruation increases the likelihood of hot flushes and nights sweats decades later at menopause, according to a University of Queensland study. School of Public Health researchers analysed data from more than 18,000 middle aged women across the UK, USA and Australia, as part of the Life course Approach to reproductive health and Chronic […]

As cancer cells evolve, many of their genes become overactive while others are turned down. These genetic changes can help tumors grow out of control and become more aggressive, adapt to changing conditions, and eventually lead the tumor to metastasize and spread elsewhere in the body. MIT and Harvard University […]

The inflammatory molecule interleukin-17A (IL-17A) triggers immune cells that in turn reduce IL-17A’s pro-inflammatory activity, according to a study by the National Eye Institute (NEI) researchers. In models of autoimmune diseases of the eye and brain, blocking IL-17A increased the presence of other inflammatory molecules produced by Th17 cells, immune […]

Proper embryonic development of the fruit fly Drosophila melanogaster is governed by patterns of protein activity bequeathed to the fertilized egg by its mother. While the embryo is still a single cell, the maternal cells surrounding it deposit certain proteins inside it at specific locations. This establishes protein gradients that direct the […]

Don’t use it, lose it. This old saying applies to so many areas of life, but also your mental capacity. You need to stimulate your brain in order to protect your cognitive ability from the horrors of aging. And you know what stimulates brain? Human contact – a new UCL-lead […]

Many people with autism experience sensory hypersensitivity, attention deficits, and sleep disruption. One brain region that has been implicated in these symptoms is the thalamic reticular nucleus (TRN), which is believed to act as a gatekeeper for sensory information flowing to the cortex. A team of researchers from MIT and […]

About 40 percent of children around the globe suffer from anemia because they do not consume enough iron. Now, studies by ETH researchers show that iron deficiency also reduces the protection provided by vaccinations. Despite the fact that global immunization programs are now reaching more people than ever, about 1.5 […]