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Research by the universities of Liverpool and Oxford reveals new insight into age-related fertility decline in male fruit flies. Infertility is one of the most striking effects of ageing. The impact of ageing on females’ fertility is more severe and much better understood, but it also affects males. Male reproductive […]

First study of its kind shows formula-fed babies’ gut microbiomes more like those of breastfed babies when they live near natural environments. Living close to natural green space can mitigate some of the changes in infant gut bacteria associated with formula feeding, according to new research published in the journal Environment International. “Not […]

Volunteers can add data with a five-minute online session. Do you get nervous when you can’t think of a word? Chances are it’s a momentary lapse, but problems with language are one of the symptoms that can indicate a neurodegenerative disorder like Alzheimer’s disease. Unfortunately, diagnosing these conditions requires scoring […]

A new study from Penn Medicine lends further evidence that the social behaviors tied to autism spectrum disorders (ASD) emerge from the abnormal function of sensory neurons outside the brain. It’s an important finding, published in the journal Cell Reports because peripheral sensory systems—which determine how we perceive the environment around us […]

To make new memories, our brain cells first must find one another. Small protrusions that bud out from the ends of neurons’ long, branching tentacles dock neurons together so they can talk. These ports of cellular chatter – called synapses, and found in the trillions throughout the brain – allow […]

A new model of the causes of breast cancer, created by a team led by researchers at UC San Francisco, Genentech and Stanford University, is designed to capture the complex interrelationships between dozens of primary and secondary breast cancer causes and stimulate further research. Breast cancer is the most common […]

Black men in the United States are known to suffer disproportionately from prostate cancer, but few studies have investigated whether genetic differences in prostate tumors could have anything to do with these health disparities. Now, in the largest study of its kind to date, researchers from Boston University School of […]

A little-studied liver protein may be responsible for the well-known benefits of exercise on the aging brain, according to a new study in mice by scientists in the UC San Francisco Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research. The findings could lead to new therapies to […]

UW microbiologists discovered a bacterial toxin that, when engineered, is a key part of a gene editor that can make single-base changes in human mitochondria. The genome in mitochondria — the cell’s energy-producing organelles — is involved in disease and key biological functions, and the ability to precisely alter this […]

Changes in a few small molecules involved in a cell’s metabolism seem to indicate whether a restricted “life extension” diet will actually extend, shorten, or have no effect on lifespan, a study of fruit flies has found. The findings suggest that analyzing the level of small molecules in cells, an […]

A research team from Yale and Baylor College of Medicine has completed the largest single-cell analysis to date of lungs affected by Idiopathic Pulmonary Fibrosis (IPF), revealing how cells change in response to the disease and identifying previously unknown cell types. The findings, published in the issue of Science Advances, deepen […]

There are innumerable studies showing small gains in mouse life span. Most cannot be reproduced, particularly the older ones, those that took place before it was common knowledge in the research community that one has to very aggressively control for accidental calorie restriction. If an intervention makes mice eat less, […]

In recent years academic interest has grown in the study of the gut microbiome. Researchers are making inroads into understanding the considerable influence of these microbial populations over the progression of health and aging. The gut microbiome may be as influential as physical activity in these matters. The balance of […]

Emory University researchers have shown that Zika virus infection soon after birth leads to long-term brain and behavior problems, including persistent socioemotional, cognitive and motor deficits, as well as abnormalities in brain structure and function. This study is one of the first to shed light on the potential long-term effects […]

A novel study from the Institute of Environmental Medicine at Karolinska Institutet indicates that antibodies against a small lipid entity, phosphorylcholine (PC), can be associated with protection in inflammatory systemic diseases, including SLE and Sjögren´s syndrome. The results support evidence for a potential treatment by providing antibodies (anti-PC) to patients […]

A sizable portion of the variable efficacy of first generation stem cell therapies as presently practiced may be due to a poor quality of cells following expansion in culture. Regardless of quality, near all such cells die shortly after transplantation. Few clinics and few approaches to cell therapy lead to […]

Why do we age? What exactly happens in the body? And: Can something be done about it? These are questions that have occupied science since time immemorial. The pharmacists Alexandra K. Kiemer and Jessica Hoppstädter from the Saarland University have not found a philosophical stone. But: they have uncovered processes […]

Everyone is aging – time is not choosing its victims. You start of young and beautiful and energized, but eventually your body and mind start falling behind and you have to retire. But when would be an appropriate time to retire? Scientists from the Newcastle University say that 50 year […]

Aichi Cancer Center(1) and NEC Corporation (NEC; 6701) today announced the launch of fundamental research aiming to realize the promise of advanced personalized cancer immunotherapy by improving the performance of NEC's neoantigen prediction system and developing predictive biomarkers for patient stratification through the fusion of AI and experimental immunology. This […]

Eating black raspberries might reduce inflammation associated with skin allergies, a new study indicates. In a study done with mice and published earlier in the journal Nutrients, researchers found that a diet high in black raspberries reduced inflammation from contact hypersensitivity – a condition that causes redness and inflammation in […]

Researchers at Karolinska Institutet have imaged tau protein in the brains of living patients with Alzheimer’s disease. The amount and spread of tau proved a predictor of future memory loss. Brain imaging for measuring tau can be useful both for improving diagnosis and for developing more effective treatments, say the […]

Research produces dramatic results in laboratory studies involving fatal myelin disease that strikes children. A team led by Case Western Reserve University medical researchers has developed a potential treatment method for Pelizaeus-Merzbacher disease (PMD), a fatal neurological disorder that produces severe movement, motor and cognitive dysfunction in children. It results […]

Senolytic drugs that destroy senescent cells, and later on, other senotherapies that either prevent senescence or block the senescence-associated secretory phenotype (SASP), are going to be very important in the treatment of aging. Senescent cells accumulate with age and are highly damaging to tissues. Via the SASP, even comparatively small […]

The age-related decline of the immune system has several causes, but the involution of the thymus is an important one. The thymus is responsible for the production of mature T cells of the adaptive immune system, but the organ atrophies with age. The supply of new T cells falls off […]

There is no situation so terrible that it will not be silently accepted as set in stone, only given that it has lasted for long enough to become routine. So it is with aging, and all of the pain, suffering, and death that accompanies it. The present furor surrounding COVID-19 […]

Increasing abdominal girth and shrinking muscles are two common side effects of aging. Researchers at the University of Bonn have discovered a receptor in mice that regulates both effects. Experiments with human cell cultures suggest that the corresponding signaling pathways might also exist in humans. The study, which also involved […]

Some studies take months to complete, some take years and some can even take decades. When scientists from the University of Birmingham set out to research what kind of effects infant sleep problems have for their adult life, they knew that this study will take a long time. And it […]

Naked mole-rats can live for an incredibly long time and have an exceptional resistance to cancer thanks to unique conditions in their bodies that stop cancer cells multiplying, according to new research. Understanding how these remarkable animals are almost completely immune to cancer could improve our understanding of the early stages […]

By mapping molecular changes in the genome over time, UC San Diego researchers developed a formula to more accurately compare dog age to human age—a tool that could also help them evaluate how well anti-aging products work. If there’s one myth that has persisted through the years without much evidence, […]

Researchers at the University of Alberta have found a way to deliver anti-cancer drugs with more precision, which could increase the effectiveness of many cancer treatments. U of A oncologist Frank Wuest altered the surface of nanoparticles, which are well suited to deliver drugs, with epidermal growth factor (EGF), a peptide that […]