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Infertility affects one in seven men of reproductive age worldwide. One idea for treating male sterility is spermatogonial stem cell (SSC) therapy. In this approach, sperm stem cells in the testis are transferred to a test tube, cultured and nudged into becoming fully fledged sperm. However, a key bottleneck has […]

Molecular biologists and bioengineers at the University of California San Diego have unraveled key mechanisms behind the mysteries of aging. They isolated two distinct paths that cells travel during aging and engineered a new way to genetically program these processes to extend lifespan. The research was described in the journal […]

A unique nanoparticle to deliver a localized cancer treatment inhibits tumor growth in mice, according to a team of Penn State researchers. The nanoparticles, developed by Daniel Hayes, associate professor of biomedical engineering, have a specific chemistry that allows a microRNA (miRNA) to attach to it. A miRNA is a […]

It might seem as though humans have little in common with the lowly yeast cell. Humans have hair, skin, muscles, and bones, among other attributes. Yeast has, well, none of those things. But besides their obvious differences, yeast, and humans, and much of life for that matter, have a great […]

Ultrasound imaging, as most people are familiar with it, is used for taking pictures of a fetus while it is still inside the womb, but it has other medical purposes, such as diagnosing diseases of organs and tissues. For years, Caltech's Mikhail Shapiro has been working to extend ultrasound imaging into […]

New study sheds light on how nutrient-starved cells recycle internal components. The idea of the cell as a city is a common introduction to biology, conjuring depictions of the cell’s organelles as power plants, factories, roads, libraries, warehouses and more. Like a city, these structures require a great deal of […]

For every cell in the body there comes a time when it must decide what it wants to do for the rest of its life. In an article published in the journal PNAS, National Institutes of Health researchers report for the first time that ancient viral genes that were once […]

The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center, together with the Sackler School of Medicine and Sagol School of Neuroscience at Tel Aviv University, announced today that a peer-reviewed study has demonstrated for the first time that hyperbaric oxygen therapy (HBOT) can significantly enhance the cognitive performance of healthy older adults. […]

Researchers from the Penn Institute of Immunology discovered three distinct immune responses to the SARS-CoV2 infection that could help predict the trajectory of disease in severe COVID-19 patients and may ultimately inform how to best treat them. The findings were published in Science. “For patients who are hospitalized with COVID-19, there isn’t just […]

In a groundbreaking new study, researchers at the University of Minnesota have 3D printed a functioning centimeter-scale human heart pump in the lab. The discovery could have major implications for studying heart disease, the leading cause of death in the United States killing more than 600,000 people a year. The […]

The development of the mammalian placenta depends upon an unusual twist that separates DNA’s classic double helix into a single-stranded form, Yale researchers report in the journal Nature. The Yale team also identified the molecular regulator that acts upon this single strand to accelerate or stop placental development, a discovery with […]

Yale pharmacology professor Barbara Ehrlich and her team have uncovered a mechanism driving a rare, lethal disease called Wolfram Syndrome and also a potential treatment. Their findings appear in the Proceedings of the National Academy of Sciences. Wolfram Syndrome — a progressive degenerative disease that affects about one in 500,000 people worldwide […]

The DNA-cutting proteins central to CRISPR-Cas9 and related gene-editing tools originally came from bacteria, but a newfound variety of Cas proteins apparently evolved in viruses that infect bacteria. The new Cas proteins were found in the largest known bacteria-infecting viruses, called bacteriophages, and are the most compact working Cas variants […]

With the growing interest in the accumulation of senescent cells as an important cause of aging, and more funding flowing into this part of the field, researchers are uncovering numerous direct links between cellular senescence and age-related conditions. Senescent cells cause harm to tissues via their inflammatory secretions, the senescence-associated […]

The emergency rooms in Barcelona were collapsing under the pressure. Hundreds of patients were arriving in desperate need as they struggled to breathe, while intensive care units struggled to cope with the sudden influx of respiratory problems. Epidemiologists scrambled to trace the source of the outbreak. This epidemic in the […]

What can the common fruit fly teach us about cancer? “Over the last few decades, the fruit fly – Drosophila melanogaster – has become a successful model for studying human cancers,” said Wu-Min Deng, Ph.D., professor of biochemistry and molecular biology and the Gerald and Flora Jo Mansfield Piltz Professor of […]

Peter Reddien's lab at the Whitehead Institute takes a step forward in understanding how neural circuits could be regenerated in adults. If anything happens to the eyes of the tiny, freshwater-dwelling planarian Schmidtea mediterranea, they can grow them back within just a few days. How they do this is a scientific conundrum […]

Stem cell activity declines with age throughout the body. In some cases this is because stem cells become less active in response to changes in the signaling environment. In other cases, the cells are damaged or the populations greatly reduced. The consequence of this decline is that fewer daughter somatic […]

Researchers at the University of East Anglia and the University of Manchester have made an important breakthrough that could lead to ‘kinder’ treatments for children with bone cancer, and save lives. Current treatment is grueling, with outdated chemotherapy cocktails and limb amputation. But despite all of this, the five-year survival […]

In a study published in PNAS, researchers from Karolinska Institutet, the Royal Institute of Technology (KTH), Nagoya University and Technische Universität Braunschweig show an undiscovered heterogeneity of adult zebrafish Purkinje cells, revealing the existence of anatomically and functionally distinct cell types. The cerebellum, sometimes referred to as the “tree of […]

Brain cancers have long been thought of as being resistant to treatments because of the presence of multiple types of cancer cells within each tumor. A new study uncovers a cancer cell hierarchy that originates from a single cancer cell type, which can be targeted to slow cancer growth. The […]

A new study from McGill University shows that increases in the concentrations of blood sodium can have an influence on the biological clock of mice, opening new research avenues for potentially treating the negative effects associated with long-distance travel or shift work. The findings, published in Nature by former McGill Ph.D. student […]

Research has found that those living with HIV have a higher risk for certain kinds of cancers—such as lung cancer. Now, with a new five-year, $3.7 million grant from the National Cancer Institute (NCI), researchers from Case Western Reserve University hope to find out why. Ge Jin, professor at the […]

A University of Michigan-led study is shedding new light on the way pancreatic cancer cells turn nearby connective tissue cells into co-conspirators in their deadly growth. The findings, which appear in Nature Metabolism, also suggest a new potential strategy against pancreatic cancer by identifying critical components of metabolic cross-talk between cells that might be […]

If you’ve ever been diagnosed with high cholesterol, also known as hyperlipidemia, your doctor has probably prescribed a statin. And while statins have been the go-to drug for managing cholesterol for nearly 25 years, there’s a new weapon in the fight. Recent studies suggest that adding a new class of medications — either […]

Researchers at Harvard Medical School, the Broad Institute of MIT and Harvard and Brigham and Women’s Hospital have uncovered a genetic mechanism that helps drive clonal hematopoiesis, a common age-related condition known to increase the risk of blood cancer and cardiovascular disease. In clonal hematopoiesis or CH, some blood stem […]

A study from the National Institutes of Health showed that neurofilament light chain (NfL) delivered a superior diagnostic and prognostic performance as a blood biomarker for mild, moderate, and severe traumatic brain injury (TBI) when compared to blood proteins glial fibrillary acidic protein, tau, and ubiquitin c-terminal hydrolase-L1. The research […]

The disposibility theory of aging is one of numerous evolutionary theories of aging that seek to explain why aging exists and is near universal across species. In this case, aging is viewed as the inevitable result of trade-offs between resources allocated to reproduction versus resources allocated to tissue maintenance. Like […]

One of the most common misconceptions is that one human year equals seven dog years in terms of aging. However, this equivalency is misleading and has been consistently dismissed by veterinarians. A recent study, published in the journal Cell Systems(link is external), lays out a new framework for comparing dog-to-human aging. In […]

Research by the universities of Liverpool and Oxford reveals new insight into age-related fertility decline in male fruit flies. Infertility is one of the most striking effects of ageing. The impact of ageing on females’ fertility is more severe and much better understood, but it also affects males. Male reproductive […]