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The COVID-19 pandemic demands action on many fronts, from prevention to testing to treatment. Not content to focus its research efforts on just one, the laboratory of George Church in the Blavatnik Institute at Harvard Medical School and the Wyss Institute for Biologically Inspired Engineering at Harvard University is tackling the problem from […]

Physical exercise can act prophylactically for people with metabolic syndrome and protect them against cardiovascular diseases, a new study from the Swedish School of Sport and Health Sciences, GIH, and Karolinska Institutet published in the European Journal of Preventive Cardiology reports. Even light physical exercise has been shown to have […]

PNNL staff scientist Kristoffer Brandvold will lead a joint team of researchers in the new partnership. The internal clock that tells our bodies when to sleep, wake, and eat each day could be regulated by more than light exposure and caffeine consumption. Scientists at Pacific Northwest National Laboratory have recently formed a […]

Babies born prematurely who require treatment to prevent blindness from retinopathy of prematurity (ROP) could be treated with a dose of Avastin (bevacizumab) that is a fraction of the dose commonly used for ROP currently. Results from the dose-finding study were published in JAMA Ophthalmology. The study was conducted by […]

Using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing cells and used the gene-editing tool CRISPR-Cas9 to correct a genetic defect that had caused the syndrome. They then implanted […]

A team of University of Alberta engineers is refining a new imaging technique that could reduce the number of repeat surgeries patients undergo to remove cancerous tumors. The team, led by Roger Zemp, is using ultraviolet photoacoustic remote sensing microscopy (UV-PARS) to rapidly visualize and analyze tumor tissue while patients are […]

COVID-19 pandemic already caused almost 200 thousand deaths worldwide. And this is assuming the official data from all countries is accurate. This is a huge loss of life, which would be even worse if countries didn’t implement quarantine regiment. But how many years of life have we actually lost? Everyone […]

A genetic change increases the risk of developing schizophrenia and highlights new opportunities for drug treatment say researchers. The collaborative research by a team from Lancaster, Glasgow and Strathclyde Universities was funded by the Medical Research Council. In the human genome, small sections of DNA have been found to be duplicated (copied) […]

A bioengineer at The University of Texas at Arlington is developing an imaging technique and a special electrocardiogram (EKG) for zebrafish to determine why they are able to regenerate their heart tissue after cardiac arrest. The research could provide crucial insights into one of the United States’ most pressing health […]

Biologist Cornelia Dulac has been missing since 2014. Her audiotapes were discovered at a remote cabin in Eastern Finland together with a fully-equipped research laboratory and a year’s supply of food. It is obvious that something had deviated from Dulac’s plans. She had been researching hydra, an immortal freshwater polyp. The authors […]

Clinicians classify frailty in a symptomatic way, looking at factors such as weight loss, weakness, walking speed, and so forth. This is a method of assessment designed for use with elderly people, but researchers here apply it to a study population that includes people in the 40-60 age range. They find that […]

In this open access paper, researchers present evidence to suggest that the mitochondrial dysfunction that accompanies aging may be a meaningful cause of the loss of neurons that contributes age-related hearing loss, in the sense that it increases the incidence of necroptosis, a form of programmed cell death. Present thinking on the progressive deafness of […]

A new study led by the University of Bristol has shown a common eye condition, glaucoma could be successfully treated with a single injection using gene therapy, which would improve treatment options, effectiveness and quality of life for many patients. Glaucoma affects over 64 million people worldwide and is a […]

Can staying up late make you fat? A growing body of research has suggested that poor sleep quality is linked to an increased risk of obesity by deregulating appetite, which in turn leads to more calorie consumption. But a new study published in PLOS Biology found that the direction of this […]

National Eye Institute (NEI) researchers profiling epigenomic changes in light-sensing mouse photoreceptors have a clearer picture of how age-related eye diseases may be linked to age-related changes in the regulation of gene expression. The findings, published online in Cell Reports, suggest that the epigenome could be targeted as a therapeutic […]

From an evolutionary perspective, human pregnancy is quite strange, says University at Buffalo biologist Vincent Lynch. “For example, we don’t know why human women go into labor,” Lynch says. “Human pregnancy tends to last longer than pregnancy in other mammals if you adjust for factors like body size. The actual […]

Experts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer’s disease. Researchers used the “molecular scissors” of CRISPR/Cas9 to search for new genes related to neurodegenerative disease. The exact causes of Alzheimer’s disease remain unknown, but one of the most well- supported […]

Viruses are nature's Trojan horses: They gain entrance to cells, smuggle in their genetic material, and use the cell's own machinery to replicate. For decades, scientists have studied how to minimize their deleterious effects and even repurpose these invaders to deliver not their own viral genome, but therapeutics for treating […]

A team of scientists led by the University of Michigan Rogel Cancer Center and Case Comprehensive Cancer Center has identified the binding site where drug compounds could activate a key braking mechanism against the runaway growth of many types of cancer. The discovery marks a critical step toward developing a potential new class of anti-cancer drugs […]

The insides of living cells can be seen in their natural state in greater detail than ever before using a new technique developed by researchers in Japan. This advance should help reveal the complex and fragile biological interactions of medical mysteries, like how stem cells develop or how to deliver […]

A blood test may be able to detect the most common form of pancreatic cancer while it is still in its early stages while also helping doctors accurately stage a patient’s disease and guide them to the appropriate treatment. A multidisciplinary study from the University of Pennsylvania found the test – known […]

Even after they quit smoking, some people can’t breathe easy. The chronic bronchitis and emphysema that can afflict long-term smokers, called chronic obstructive pulmonary disease COPD, never goes away and may even progress despite the smoker quitting. Now, researchers from UConn Health and the University of Houston report the journal […]

A team of researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia, a type of cancer that remains difficult to treat and is marked by frequent relapse. “We used CRISPR technology to carry […]

Researchers from Karolinska Institutet in collaboration with a lab in San Antonio USA, have uncovered how a specific population of lymphocytes promotes autoimmune disease by giving up their regulatory role in the immune system. The newly discovered mechanism is published in PNAS from research led by Dr. Saikiran Sedimbi and […]

Researchers have harnessed the power of electronic health records to gain insight in the potential of inflammation-controlling medications to reduce a patient’s Alzheimer’s disease risk. Rong Xu, professor of Biomedical Informatics and director of the Center for Artificial Intelligence in Drug Discovery at Case Western Reserve University; Mark Gurney, chairman […]

Before CRISPR became a household name as a tool for gene editing, researchers had been studying this unique family of DNA sequences and its role in the bacterial immune response to viruses. The region of the bacterial genome known as the CRISPR cassette contains pieces of viral genomes, a genomic […]

Despite centuries-long efforts to develop cures for cancer, various forms of the disease will kill about 630,000 people in the U.S. in 2020. But hopes are rising for cell therapies – sometimes called “living medicines” – that can boost and adapt the natural cancer-fighting potential of the immune system in ways […]

The conclusion to today's open access paper opens with the following declaration: “There is still no agreement among gerontologists as to the main aging-related issue: whether it is an accidental accumulation of damage in the organism or a result of the operation of a specially evolved program.” This is true in the […]

The CellAge database was announced last year, a repository of information on genes linked to cellular senescence. Cells become senescent in response to a variety of stresses, or upon reaching the Hayflick limit. A senescent cell ceases replication and secretes inflammatory and pro-growth signals. The process serves a useful function when such cells are present for […]

The size of the contribution of stochastic nuclear DNA damage to aging is debated. It causes cancer, when rare combinations of cancerous mutations occur and suppression of those early cancerous cells fails, but can it give rise to a meaningful degree of tissue dysfunction otherwise? The present consensus is that most such […]