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After years of research on cell surface receptors called Frizzleds, researchers at Karolinska Institutet provide the proof-of-principle that these receptors are druggable by small molecules. The results, which are published in the scientific journal Nature Communications, open for new strategies to treat different types of cancer. For more than 20 […]

Like motley bandits, certain enzymes implicated in cancer and other diseases also annihilate each other. A new study reveals details of their mutual foils in the hopes that these behaviors can be leveraged to fight the enzymes’ disease potential. The bandits are cathepsins, enzymes that normally dispose of unneeded protein […]

Employing advanced technologies that allow whole brain imaging at single-cell resolution, researchers at University of California San Diego School of Medicine report that in an alcohol-dependent mouse model, the rodent brain’s functional architecture is substantially remodeled. But when deprived of alcohol, the mice displayed increased coordinated brain activity and reduced […]

For most patients, melanoma begins with a small, pigmented spot on their skin that they notice starts to change. Many primary melanomas can be cured by having this lesion removed, but melanoma can also recur and spread; an analysis of the removed lesion can offer some information on the likelihood […]

T-cell therapies for cancer – where immune cells are removed, modified and returned to the patient’s blood to seek and destroy cancer cells – are the latest paradigm in cancer treatments. The most widely-used therapy, known as CAR-T, is personalized to each patient but targets only a few types of […]

Endogenous proteins that play a vital part in allergies and parasitic infection can prevent the immune system from wrongly attacking the body and causing inflamed joints, a study from Karolinska Institutet published in the scientific journal PNAS reports. The researchers hope that the results will give rise to new drugs […]

New research has shown that by changing the time course of voltage change early when the heart cell contracts it is possible to both withhold a potentially lethal electrical disturbance and improve the strength of cardiac contraction in heart failure at the same time. The research led by the University […]

Milk is among those product that we would find in most shopping baskets in most stores at any time. People drink it straight and use it for cooking. But which one is better – whole, low fat or nonfat? Which one will help you live longer? Biological age is a […]

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age. In a new paper, published in the journal Aging Cell, researchers at University of California San Diego School of Medicine say the gene appears to play a key role […]

Zika virus infection can stunt neonatal brain development, a condition known as microcephaly, in which babies are born with abnormally small heads. To determine how best to prevent and treat the viral infection, scientists first need to understand how the pathogen gets inside brain cells. Employing different approaches to answer […]

Breastfeeding mothers may be encouraged to eat eggs to help prevent babies from developing an egg allergy, according to new studies by researchers at The University of Western Australia. Study leader Professor Valerie Verhasselt, from UWA’s School of Molecular Sciences, said the findings were important because in western countries up […]

A way in which some connections between brain cells can resist degeneration – a hallmark of traumatic brain injuries and neurodegenerative diseases — has been discovered by researchers at The University of Queensland. Dr Sean Coakley and Professor Massimo Hilliard from UQ’s Queensland Brain Institute Clem Jones Centre for Ageing Dementia Research uncovered a way in […]

Acid reflux drugs that are sometimes recommended to ease stomach problems during cancer treatment may have an unintended side effect: impairment of breast cancer survivors’ memory and concentration. New Ohio State University research shows an association between breast cancer survivors’ use of proton pump inhibitors (PPIs) and reports of problems with […]

A common and inexpensive drug may be used to counteract treatment resistance in patients with acute myeloid leukemia (AML), one of the most common forms of blood cancer. This is the conclusion of a study in mice and human blood cells performed at Karolinska Institutet and SciLifeLab and published in […]

It’s easy to brush off the early signs of myositis, a muscle weakening autoimmune disease. That trip or fall while walking could be attributed to clumsiness. Difficulty climbing up stairs, rising from a chair or lifting something overhead could be from an abandoned regular exercise program or muscle breakdown from […]

Research by University at Buffalo biologists is providing new insights into alpha-synuclein, a small acidic protein associated with Parkinson’s disease. Alpha-synuclein is known to form abnormal clumps in the brains of patients with Parkinson’s, but scientists are still trying to understand how and why this happens. The new study explores […]

A recent study by a team of University at Buffalo researchers has found a link between fats in the blood and problems with the arteries in people with multiple sclerosis (MS). The purpose of the study, which was published online ahead of print in the Journal of Vascular Research, was to […]

New UC Riverside research shows soybean oil not only leads to obesity and diabetes, but could also affect neurological conditions like autism, Alzheimer’s disease, anxiety, and depression. Used for fast food frying, added to packaged foods, and fed to livestock, soybean oil is by far the most widely produced and […]

Yale doctors have developed a way to create vascular grafts from stem cells that are as strong as the original blood vessels they would replace. The advance, demonstrated in an animal model, may lead to bioengineered grafts suitable for transplant into any human patient using universally compatible cell lines, said […]

Researchers at Linköping University have developed a method that can identify which eggs will become cockerels on the same day they are laid, before an embryo has developed. There are approximately 7.5 million laying hens in Sweden, according to the Swedish Board of Agriculture. Turnover in the population is more […]

Sperm are influenced by diet, and the effects arise rapidly. This is the conclusion of a study by researchers at Linköping University, in which healthy young men were fed a diet rich in sugar. The study, which has been published in PLOS Biology, gives new insight into the function of […]

By combining electron microscopy (EM) with the latest super-resolution microscopy (SR), Howard Hughes Medical Institute (HHMI) and UC Berkeley scientists have obtained exquisitely detailed views of the complex innards of cells, all in 3D. In a report in the issue of the journal Science, the researchers describe their technique, called […]

A University at Buffalo biomedical engineer is gaining recognition outside the United States for his work using high-tech devices to diagnose and ameliorate neurological conditions. Anirban Dutta, PhD, assistant professor in the Department of Biomedical Engineering, has been in India, participating in a collaborative project that pairs a virtual reality-based […]

From veins that deliver oxygen to tissues to xylem that send water into stems and leaves, vascular networks are a crucial component of life. In biology, there is a wide range of unique patterns, like the individualized structures found on leaves, along with many conserved structures, such as named arteries […]

A new study, published in PeerJ, shows how University of Liverpool researchers have used a newly developed eye movement test to improve the understanding of how parts of the brain work. Healthy, older adults are widely reported to experience cognitive decline, including impairments in inhibitory control (the ability to stop ourselves […]

Vanderbilt University neuroscientist James R. Booth is publicly releasing two large scale neuroimaging datasets on reading and language development to support other researchers across the world who are working to understand how academic skills development in childhood. “We have been able to follow our curiosity and answer some really interesting questions […]

Studies that started in zebrafish have now pointed to a role for collagen secretion in a wide variety of clinical symptoms — and in a newly identified genetic syndrome. Ela Knapik, MD, associate professor of Medicine at Vanderbilt University Medical Center, and her colleagues discovered the syndrome caused by mutation […]

UK scientists have identified a new way to kill pancreatic cancer cells by ‘pulling the plug’ on the energy generator that fuels calcium pumps on their cell surface. The study, published in the British Journal of Cancer, reports how switching off the cancer’s energy supply causes the pancreatic cancer cells to […]

Epigenetic changes occur in the DNA of breast cancer cells that have developed a resistance to hormone therapy, an effective treatment for ER+ breast cancer, which accounts for 70% of all diagnoses. Reversing these changes, researchers say, has significant potential to help reduce breast cancer relapse. A team led by […]

A woman’s supply of eggs is finite, so it is crucial that the quality of their genetic material is ensured. New work from Carnegie’s Marla Tharp, Safia Malki, and Alex Bortvin elucidates a mechanism by which, even before birth, the body tries to eliminate egg cells of the poorest quality. […]