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Researchers have known for decades that inflammation accompanies Alzheimer’s disease (AD) brain lesions. Several early studies suggested that “super-aspirins” or Nonsteroidal anti-inflammatory drugs (NSAID) could help avoid the disease. However, after clinical trials showed that NSAIDs don’t help patients who already have AD symptoms, doctors wondered whether these drugs could […]

Researchers at Karolinska Institutet present a publicly available resource that can accelerate the use of so-called FISH techniques for studying how the genome is spatially organised in the cell nucleus. The new platform, which enables more cost-effective analyses for both research and diagnostic labs, is described in the scientific journal Nature […]

The next cancer therapy could be a patient’s own cells. Tactiva Therapeutics, a Buffalo-based immuno-oncology startup, is developing a personalized cancer treatment based on engineered immune cells derived from patients’ own cells. The company’s approach involves attaching proteins called receptors to these cells. The receptors target antigens present in cancer […]

This may help identify the cause of the cancer, so that the children can receive more precise treatment in the long term and avoid unnecessary side effects. Personalized medicine is now a reality for Danish children with cancer. If children can be prevented from dying from the disease, receive a […]

If caught early, nearly all cases of colon cancer are curable. Though this should make screening tests straightforward, colon cancer screening suffers from a paradoxical combination of low compliance rates and overdiagnosis. In a study published in the Proceedings of the National Academy of Sciences, University of Wisconsin–Madison scientists identified four blood-based fingerprints – […]

Results from NASA’s landmark Twins Study, which took place from 2015-2016, were published Thursday in Science. The integrated paper — encompassing work from 10 research teams — reveals some interesting, surprising and reassuring data about how one human body adapted to — and recovered from — the extreme environment of space. The Twins Study provides the […]

Yale scientists with colleagues at University College London have taken the next step towards unravelling how cells work together during wound closure, a question that could be fundamental to determining optimal healing rates after injury or disease. How cells behave, the rate at which they repair skin tissue, and how […]

Recent advances in the development of cancer therapies have increased long-term survival and prognosis. However, the increased burden and prevalence of harmful side effects, including cardiomyopathy, have emerged alongside those therapeutic benefits. In particular, there have been increases in cancer therapy-induced cardiomyopathy (CCM) — a heart condition which may compromise […]

The ability of cancer to establish itself in distant parts of the body — called metastasis — causes 90% of deaths from solid tumors. Metastasis is the result of complex genetic interactions that have proven difficult for scientists to study. Now Yale researchers have devised a way to identify some […]

Rare types of cervical cancer can be effectively prevented with screening, a comprehensive study of identified cases of rare cervical cancer over a ten-year period in Sweden concludes. The study was conducted by researchers at Karolinska Institutet and is published in The BMJ. The main aim of cervical screening is to […]

University of Maryland researchers analyzed a DNA-based evolutionary tree for a majority of known bat species and found four bat lineages that exhibit extreme longevity. They also identified for the first time two traits that predict extended life spans in bats. Their work is described in a research paper, published […]

By speaking the brain’s language, the material is a portal between electronics and the brain. WEST LAFAYETTE, Ind. — What if the brain could detect its own disease? Researchers have been trying to create a material that “thinks” like the brain does, which would be more sensitive to early signs […]

Researchers find new way to clean up cells; discovery could aid attack on human disease. Marie Kondo herself couldn’t do it any better. Usually cells are good at recognizing what doesn’t spark joy. They’re constantly cleaning house — picking through their own stuff to clear out what no longer works. […]

There could be new treatments on the horizon for diffuse intrinsic pontine glioma, or DIPG, a devastating form of brain cancer that afflicts young children and is currently incurable. Recent experiments in animal models of the disease have identified an experimental drug that effectively destroys DIPG cells. And a team […]

The ability to turn while walking is impaired among patients with Parkinson's disease. This difficulty is also associated with freezing of gait and falls, which can have devastating medical consequences in an older population. A new Tel Aviv University study advances the understanding of turns in Parkinson's patients, providing new insights into […]

Some of the deadliest cancers have mostly silent symptoms. By the time people go to their doctors because of worrisome changes, cancer may have already reached a late stage, giving physicians limited treatment options. Scientists are always looking for ways to detect cancer and other diseases through tests that show […]

Leukemia treatments often leave girls infertile, but a procedure developed by researchers at the University of Michigan working with mice is a step toward restoring their ability to be biological mothers. Ovarian follicles are the “nests” that carry eggs and support them to grow and become viable. The researchers demonstrated […]

University at Buffalo researchers have developed a new method to more accurately predict tumor growth rates, a crucial statistic used to schedule screenings and set dosing regimens in cancer treatment. The mathematical method successfully estimated the doubling time — the amount of time for a tumor to double in size […]

Purdue University researchers have developed a new design method to create soft robots that may help in caregiving for elderly family members. WEST LAFAYETTE, Ind. – The world’s elderly population is booming. The number of older people — those age 60 years or older — is expected to more than […]

Chronological aging is easy to track – birthdays. Biological aging can be obvious too – graying hair, sagging skin, and other inexorable signs of impending decrepitude. But measuring biological aging isn’t as easy as noting the passage of time. The best-studied measure of biological age is the shrinking of chromosome tips, or telomeres, […]

Scientists have known for decades that caloric restriction leads to a longer lifespan. It has also been observed that chronic inflammation increases with age. But any relationship between the two had remained unexplored. But in a new study, published in Cell Metabolism,  Harvard Medical School researchers at Joslin Diabetes Center have uncovered […]

In a first on the quest to cure HIV, University of Pittsburgh Graduate School of Public Health scientists report in EBioMedicine that they’ve developed an all-in-one immunotherapy approach that not only kicks HIV out of hiding in the immune system, but also kills it. The key lies in immune cells designed to recognize an […]

If a picture’s worth a thousand words, a video is perhaps worth much more. For the first time, scientists have observed a dynamic localization of a single RNA with processing bodies—the membraneless organelles present in the cytoplasm of nearly all mammalian cells that play an important role in RNA regulation. […]

DTU has entered into collaboration with the UK company Kromek aimed at developing a scanner that can improve breast cancer diagnostics. Advanced technology developed for space research often has great potential in other fields. The new industrial research and development partnership between DTU Space and the UK company Kromek Group plc is a good […]

New research from Aarhus University and Aarhus University Hospital shows that women aged 65 and older have a higher risk of dying from cervical cancer than previously thought – although this age group is not covered by the Danish screening programme. Denmark has one of highest incidences of cervical cancer […]

A first-of-its-kind national study has found that a form of brain imaging that detects Alzheimer’s-related “plaques” significantly influenced clinical management of patients with mild cognitive impairment and dementia. The study revealed that providing clinicians with the results of positron emission tomography (PET) scans that identify amyloid plaques in the brain […]

A 49-year-old man notices a painless rash on his shoulder but doesn’t seek care. Months later, during a routine physical, his doctor notices the rash and diagnoses it as a benign skin condition. More time passes, and during a routine screening test, a nurse points out the rash to another […]

Colorectal cancer is the second deadliest cancer in the United States, and just six out of 10 adults in the age range recommended for routine screening—50 to 75—reported having it done in 2015. When patients do not keep up with screening, the risk of death is substantially higher, so Penn […]

Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human cancers. The initiation and progression of cancer cells occur when molecular signals involved in cellular proliferation go awry. MEK1 plays an essential role in signaling within both healthy […]

New immunotherapies can dramatically defeat cancer. But more often, cancer evades them, and doctors need to know quickly when that happens, so they can adjust treatment. An experimental urine test to detect immunotherapy effectiveness very early has received a major funding boost. The National Institutes of Health has granted $1.8 […]