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NineSigma, on behalf of Daiichi Sankyo Co., Ltd., seeks novel drug targets or seeds, which are related to the cancer-neuron axis, an interaction between the nervous system and tumour. Recent studies suggest that the nervous system including nerve cells and neural factors exaggerates cancer cell growth in the tumour microenvironment (Trends […]

In 2020, PLOS ONE announced a Call for Papers on Modeling Cell Proliferation and the Cell Microenvironment. This week, we celebrate the launch of this collection, which includes a number of papers offering new insights into this vital topic. Understanding the cellular microenvironment and how cells proliferate has a number of useful applications, and […]

Vaccines, like many other things in the world, sometimes have a negative side attached to their main positive effect of protecting us against different – and potentially lethal – diseases. Luckily, this 'negative side' has a very, very low chance of manifesting in practice. Many different tests and clinical trials […]

UCSF Proof-of-Concept Study Shows Possibilities of More Cost-Effective Cell Therapy Using ‘Universal’ Stem Cells. Scientists at UC San Francisco have shown that gene-edited cellular therapeutics can be used to successfully treat cardiovascular and pulmonary diseases, potentially paving the way for developing less expensive cellular therapies to treat diseases for which […]

As you read this text, the millions of cells that make up your body are hard at work. Within every cell is a flurry of activity keeping you alive, mostly driven by machinery that is made up of proteins. Some of this protein machinery is so important to living things […]

X-ray technology at Argonne’s Advanced Photon Source allows researchers to measure from synapse to whole brain level. Researchers at the University of Chicago and the U.S. Department of Energy’s (DOE) Argonne National Laboratory have imaged an entire mouse brain across five orders of magnitude of resolution, a step which researchers […]

Case Western Reserve University researchers studying human prions—misfolded proteins that cause lethal and incurable diseases—have, for the first time, identified surface features responsible for the replication of prions in the brain. The ultimate goal of their research is to design a strategy to stop prion disease in humans—and, ultimately, to […]

The risk of severe illness and death from SARS-CoV-2, the virus that causes Covid-19, is extremely low in children and teenagers, according to the most comprehensive analyses of public health data, led by researchers at UCL, University of Bristol, University of York and the University of Liverpool. However, catching Covid-19 […]

Researchers at McGill University have shown that a brain cell structure previously thought to be pathological in fact enhances cells’ ability to transmit information and correlates with a better learning on certain tasks. In a study published in Nature Communications, the team investigated swellings that occur in the axons of Purkinje […]

Part of Dennis Plenker’s daily job, as a Cold Spring Harbor Laboratory (CSHL) research investigator, is growing cancer. And a variety of different ones, too. Depending on the day and the project, different tumours may flourish. They might be aggressive breast cancers. They might be glioblastomas, one of the deadliest […]

Most countries have not introduced nationwide prostate cancer screening, as current methods result in overdiagnoses and excessive and unnecessary biopsies. A new study by researchers at Karolinska Institutet in Sweden, which is published in The New England Journal of Medicine, indicates that screening by magnetic resonance imaging (MRI) and targeted […]

Diabetes is the leading cause of kidney failure in the United States, but identifying type 1 or type 2 diabetes patients at high risk for progressive kidney disease has never had a sure science behind it. Historically, assessing kidney function meant looking at estimated glomerular filtration rate, a calculation that determines […]