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Today's open access editorial discusses one quite specific consequence of the age-related disruption of energy metabolism in cells. Mitochondria, the power plants of the cell, falter with age throughout the body, for complex reasons still under exploration. The proximate causes involve too little production of molecular machinery needed for the […]

Exercise is beneficial at every age, but most people do not undertake enough physical activity. In a sedentary world, structured exercise programs look like a decent therapy, because that exercise corrects a harmful deficiency in the operation of metabolism. Thus the studies showing a reduction in mortality resulting from exercise […]

Tauopathies like Alzheimer's disease are characterized by the spread of tau aggregates through the brain. Tau is one of the few molecules in the body that can become altered in a way that encourages other copies of the same molecule to also alter, causing aggregates to form. These aggregates and […]

As you may know, I co-founded Repair Biotechnologies, a company presently focused on developing an approach to rapidly reverse the cholesterol content of atherosclerotic lesions, a goal that is impossible to achieve using the existing panoply of treatments for atherosclerosis. We use gene therapy techniques to provide cells with the […]

Studying the complex causes of Alzheimer’s disease, and how to treat and prevent this condition, is like solving a many-piece puzzle, with scientists each tackling a small section, unsure of how it might fit into the larger picture. Now, researchers at Gladstone Institutes have determined how a handful of previously […]

Glutathione is a mitochondrial antioxidant, and additional antioxidant capacity in mitochondria appears to be beneficial to long-term health, improving mitochondrial function and overall health. Mitochondria conduct the energetic process of producing ATP, used to power the cell, with a flux of oxidative molecules as a side-effect. With age, mitochondria tend […]

Research from a University of Saskatchewan (USask) College of Medicine team will help develop medications that can inhibit the nerve cell damage that occurs due to diseases such as multiple sclerosis (MS). The research team has modelled the mechanisms by which a specific cell protein, A1, causes damage to nerve […]